Results 31 to 40 of about 411,997 (358)

Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context

Epigenetics & Chromatin
Background Topologically associating domains (TADs) are believed to play a role in the regulation of gene expression by constraining or guiding interactions between the regulatory elements.
Paul Salnikov, Polina Belokopytova, Alexandra Yan, Emil Viesná, Alexey Korablev, Irina Serova, Varvara Lukyanchikova, Yana Stepanchuk, Nikita Torgunakov, Savelii Tikhomirov, Veniamin Fishman   +10 more
doaj   +1 more source

Prevalence of diabetes in the adult population of Novosibirsk

Сахарный диабет, 2017
Aims. To estimate the prevalence of type 2 diabetes mellitus (T2DM) in different age groups of the adult population of Novosibirsk, according to epidemiological studies in 2003–2005 and 2013–2016. Methods.
Svetlana V. Mustafina, Oksana D. Rymar, Sofiya K. Malyutina, Diana V. Denisova, Liliya V. Shcherbakova, Mihail I. Voevoda   +5 more
doaj   +1 more source

Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study [PDF]

, 2019
The manuscript was reviewed by Jo’s Trust, which supports the conclusions. It made the following statement: We think (it has) massive implications for the screening programme, vaccine and also impact on diagnoses in the future.
Cruickshank, Margaret, Cuschieri, Kate, Kavanagh, Kim, Palmer, Tim, Pollock, Kevin G., Robertson, Chris, Wallace, Lynn   +6 more
core   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene

Nature Communications
Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the TADs boundaries do not always lead to significant changes in the activity ...
Evelyn Kabirova, Anastasiya Ryzhkova, Varvara Lukyanchikova, Anna Khabarova, Alexey Korablev, Tatyana Shnaider, Miroslav Nuriddinov, Polina Belokopytova, Alexander Smirnov, Nikita V. Khotskin, Galina Kontsevaya, Irina Serova, Nariman Battulin   +12 more
doaj   +1 more source

Usage of the cyto-genetics and cytology to identify the action mechanisms of two bio-fertilizers on Allium cepa meristematic cells

Bulletin of the National Research Centre, 2019
Background Bio-fertilizers as a safe alternative to the synthetic fertilizers come to the front in the agriculture requirements as they provide the planted crops with their nutrients to ensure high quality and productivity.
Rania T. Ali, Enas M. Abdel-Ghany, Fawzia I. Mohamed, Evon M. Hanna, Zeinab M. Elashery   +4 more
doaj   +1 more source

Emperipolesis in a Case of Adult T Cell Lymphoblastic Lymphoma (Mediastinal type)-Detected at FNAC and Imprint Cytology [PDF]

, 2011
Emperipolesis is a condition in which viable hematopoetic cells are seen intact in the cytoplasm of host cell without damage. This phenomenon is seen in many physiologic and pathologic conditions, its presence in Rosai Dorfman disease (RDD) is ...
Abhishekh, MG, Amita, K, Geethalakshmi, U, Vijay Shankar, S   +3 more
core  

Calibrating models in economic evaluation: a comparison of alternative measures of goodness of fit, parameter search strategies and convergence criteria.

, 2011
BACKGROUND: The importance of assessing the accuracy of health economic decision models is widely recognized. Many applied decision models (implicitly) assume that the process of identifying relevant values for a model's input parameters is sufficient to
Karnon, Jonathan, Vanni, Tazio
core   +1 more source

Transurethral resection and surveillance of bladder cancer supported by 5-aminolevulinic acid-induced fluorescence endoscopy [PDF]

, 1999
Purpose: We determined whether neoplastic disease, which was missed under white light can be found during transurethral resection of bladder cancer by 5-aminolevulinic acid-induced porphyrin fluorescence.
Baumgartner, Reinhold, Hofstetter, Alfons, Knüchel, Ruth, Kriegmair, Martin, Stepp, Helmut, Stepp, Herbert, Zaak, Dirk   +6 more
core   +1 more source