Results 81 to 90 of about 603,995 (406)

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

BJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek, M. Almquist, A. O. Bergenfelz, T. J. Musholt, E. Nordenström, on behalf of the EUROCRINE® Council, M. Almquist, M. Barczynski, L. Brunaud, T. Clerici, M. H. Hansen, M. Iacobone, Ö. Makay, F. F. Palazzo, N. Muñoz‐Pérez, M. Raffaelli, P. Riss, S. van Slycke, M. R. Vriens   +18 more
wiley   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

THE BIOTECHNOLOGICAL POTENTIAL OF THE NEW CROP, Miscanthus cv . SORANOVSKII

Вавиловский журнал генетики и селекции, 2015
Miscanthus cv. Soranovskii was registered as a state breeding achievement in 2013. On the base of phenotyping and DNA sequencing, the new crop was identified as Miscanthus sacchariflorus.
N. M. Slynko, T. N. Goryachkovskaya, S. V. Shekhovtsov, S. V. Bannikova, N. V. Burmakina, K. V. Starostin, A. S. Rozanov, N. N. Nechiporenko, S. G. Veprev, V. K. Shumny, N. A. Kolchanov, S. E. Peltek   +11 more
doaj  

Metabolic pathways and genes identified by RNA-seq analysis of barley near-isogenic lines differing by allelic state of the Black lemma and pericarp (Blp) gene

BMC Plant Biology, 2017
Background Some plant species have ‘melanin-like’ black seed pigmentation. However, the chemical and genetic nature of this ‘melanin-like’ black pigment have not yet been fully explored due to its complex structure and ability to withstand almost all ...
Anastasiya Y. Glagoleva, Nikolay A. Shmakov, Olesya Y. Shoeva, Gennady V. Vasiliev, Natalia V. Shatskaya, Andreas Börner, Dmitry A. Afonnikov, Elena K. Khlestkina   +7 more
doaj   +1 more source

Sensitivity of cytology in liver tumor biopsy and its significance in the prompt clinical diagnosis of non‐hepatocellular carcinoma

Cancer Medicine, 2023
Background Cytology is a fast and simple modality for identifying malignancies and tumor histology. In this study, we analyzed the sensitivity of cytology for liver tumor biopsy and evaluated its potential for prompt clinical diagnosis.
Tasuku Nakabori, Yutaro Abe, Sena Higashi, Kaori Mukai, Azusa Shingetsu, Sanako Nishimura, Sayoko Tsuzaki, Ayumi Ryu, Satoshi Tanada, Shigenori Nagata, Keiichiro Honma, Kazuyoshi Ohkawa   +11 more
doaj   +1 more source

Cytological Classification Diagnosis for Thyroid Nodules via Multimodal Model Deep Learning

Advanced Science, EarlyView.
This study introduces AI‐TFNA, an innovative artificial intelligence model designed to assist cytopathologists in classifying thyroid nodules based on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The model effectively differentiates between benign and malignant thyroid nodules, demonstrating significant potential as a screening ...
Yuanzheng Lou, Yongjian Su, Haoda Lu, Wencai Li, Weihua Yin, Shengnan Li, Huobiao Zhu, Kok Haur Ong, Gang Chen, Yong Jiang, Yifei Liu, Shenglei Li, Manchun Yang, Zhengyu Zhang, Xiaoyan Wang, Xiaohui Zhu, Xinmi Huo, Longjie Li, Chao Wang, Nanyan Zhang, Weijun Pan, Bin Shang, Xudan Yang, Yongqiang Zhu, Xiaolin Liu, Weimiao Yu, Xiuwu Bian, Yanqing Ding   +27 more
wiley   +1 more source

Long-term effects of maternal exposure to surgical stress at the earliest stage of pregnancy on blood pressure and behavior in offspring of OXYS rats

Вавиловский журнал генетики и селекции, 2018
The use of some assisted reproductive technologies, in particular, embryo transfer, may cause various physiological and behavioral changes in the offspring.
I. N. Rozhkova, T. N. Igonina, D. S. Ragaeva, O. M.  Petrova, E. Yu. Brusentsev, V. A. Naprimerov, S. Ya. Amstislavsky   +6 more
doaj   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

The effect of a single administration of streptozotocin on hippocampus metabolites in NODSCID mice

Вавиловский журнал генетики и селекции, 2018
The significant increase in the number of people diagnosed with diabetes mellitus in recent years makes studies of this problem topical. The persistent hyperglycemia accompanying the development and course of type 1 diabetes mellitus (T1DM) can affect ...
D. A. Tur, O. B. Shevelev, M. В. Sharapova, M. A. Zolotykh, A. E. Akulov   +4 more
doaj   +1 more source