Results 231 to 240 of about 179,487 (293)

Current Progress in Targeting Human Cytomegalovirus Infection

open access: yesiLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation

open access: yesiMeta, EarlyView.
Multi‐omics sequencing and correlation analysis identified the beneficial role of Faecalibacterium prausnitzii (F. prausnitzii)‐derived butyric acid (BA) as a key metabolite in the restoration of valve function in calcific aortic valve disease (CAVD). The therapeutic efficacy of BA in attenuating CAVD progression was confirmed in vitro, ex vivo, and in
Chunli Wang   +18 more
wiley   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

open access: yesiMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang   +12 more
wiley   +1 more source

Laboratory Practices for the Detection and Characterization of Cryoglobulins and Cryofibrinogen

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study shows the importance of carrying out the search for both cryoproteins, cryoglobulins, and cryofibrinogen in cases of strong clinical suspicion of cryoproteinemia, despite their complex but not impossible detection. Use of correct procedures from the pre‐preanalytical phase up to reporting, of alternative methods such as immunotyping and the ...
Teresa Troiano   +5 more
wiley   +1 more source

Contrasts or Carryover? Demands–Capabilities Fit and Task‐Level Intrinsic Motivation Across the Workday

open access: yesJournal of Organizational Behavior, EarlyView.
ABSTRACT In the course of a workday, employees attend to various tasks whose challenge might be equal to, higher than, or lower than employees' present level of capabilities. Moreover, employees encounter these tasks sequentially throughout the day with different levels of prior motivation. Investigating carryover effects in motivation from one task to
Sherry (Qiang) Fu   +4 more
wiley   +1 more source

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