Results 41 to 50 of about 122,616 (293)
Журнал инфектологии, 2014 102 pair «HIV infected pregnant women with cytomegalovirus infection – HIV negative child» were examined. Cytomegalovirus vertical transmission were realized in 20% women.
V. B. Denisenko +2 more
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Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Cytomegalovirus dynamics model with random behavior
AIMS Mathematics, 2020 In view of the particularity of cytomegalovirus infection in infants and considering the uncertainty of infection mode and treatment, a dynamic model of cytomegalovirus with random behavior is established in this paper.
Dong-Mei Li +3 more
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Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation. [PDF]
PLoS ONE, 2016 Congenital cytomegalovirus infections are a leading cause of neurodevelopmental disorders in human and represent a major health care and socio-economical burden. In contrast with this medical importance, the pathophysiological events remain poorly known.
Robin Cloarec +18 more
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Advanced Science, EarlyView.In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu +10 more
wiley +1 more source
Journal of Medical Case Reports, 2010 Introduction Cytomegalovirus is a common virus responsible for a wide range of clinical manifestations. Hemolysis is a rare but potentially life-threatening complication of cytomegalovirus infection, described mostly in immunocompromised patients, the ...
Noto Pasquale +6 more
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Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
Advanced Science, EarlyView.TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang +9 more
wiley +1 more source
Acta Biomedica Scientifica, 2016 To examine the correlation of changes of ω-6 polyunsaturated fatty acids and free-radical processes in the blood of the umbilical cord of newborns to mothers with cytomegalovirus infection, the content of ω-6 polyunsaturated arachidonic, linoleic fatty ...
N. A. Ishutina, N. N. Dorofienko
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Advanced Science, EarlyView.This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen +18 more
wiley +1 more source
JTCVS Open, 2023 Objectives: Cytomegalovirus infection after lung transplant is associated with increased morbidity and mortality. Inflammation, infection, and longer ischemic times are important risk factors for cytomegalovirus infection.
Rafaela V.P. Ribeiro, MD, PhD +9 more
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