Results 41 to 50 of about 4,161 (148)

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Adult patients with Ph+ ALL benefit from conditioning regimen of medium‐dose VP16 plus CY/TBI

Hematological Oncology, Volume 40, Issue 5, Page 1041-1055, December 2022., 2022
Abstract The medium‐dose etoposide (VP16) added on cyclophosphamide (CY)/total body irradiation (TBI) is one of the intensified myeloablative conditioning regimens used in allogenic hematopoietic stem cell transplantation (allo‐HSCT) for acute lymphoblastic leukemia (ALL).
Mari Morita‐Fujita, Yasuyuki Arai, Tadakazu Kondo, Kaito Harada, Naoyuki Uchida, Takashi Toya, Yukiyasu Ozawa, Takahiro Fukuda, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Yumiko Maruyama, Satoru Takada, Toshiro Kawakita, Takahide Ara, Tatsuo Ichinohe, Takafumi Kimura, Yoshiko Atsuta, Shinichi Kako   +18 more
wiley   +1 more source

Control of human cytomegalovirus replication by liver resident natural killer cells

Nature Communications, 2023
Natural killer cells play important roles in the immune response to human cytomegalovirus infection. Here the authors implicate donor-derived liver resident natural killer cells in the control of human cytomegalovirus infection by analysis of perfusates ...
Calum Forrest, Thomas J. G. Chase, Antonia O. Cuff, Dionas Maroulis, Reza Motallebzadeh, Amir Gander, Brian Davidson, Paul Griffiths, Victoria Male, Matthew Reeves   +9 more
doaj   +1 more source

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Secondary infections worsen the outcome of COVID‐19 in patients with hematological malignancies: A report from the ITA‐HEMA‐COV

Hematological Oncology, Volume 40, Issue 5, Page 846-856, December 2022., 2022
Abstract The impact of secondary infections (SI) on COVID‐19 outcome in patients with hematological malignancies (HM) is scarcely documented. To evaluate incidence, clinical characteristics, and outcome of SI, we analyzed the microbiologically documented SI in a large multicenter cohort of adult HM patients with COVID‐19.
Patrizia Zappasodi, Chiara Cattaneo, Virginia Valeria Ferretti, Roberto Mina, Andrés José María Ferreri, Francesco Merli, Margherita Oberti, Mauro Krampera, Alessandra Romano, Caterina Zerbi, Jacqueline Ferrari, Michele Cavo, Marco Salvini, Lorenza Bertù, Nicola Stefano Fracchiolla, Francesco Marchesi, Massimo Massaia, Vincenzo Marasco, Roberto Cairoli, Anna Maria Scattolin, Alessandro Maria Vannucchi, Carlo Gambacorti‐Passerini, Pellegrino Musto, Filippo Gherlinzoni, Antonio Cuneo, Antonello Pinto, Livio Trentin, Monica Bocchia, Sara Galimberti, Elisa Coviello, Maria Chiara Tisi, Alessandro Morotti, Brunangelo Falini, Mauro Turrini, Agostino Tafuri, Atto Billio, Massimo Gentile, Roberto Massimo Lemoli, Adriano Venditti, Matteo Giovanni Della Porta, Francesco Lanza, Luigi Rigacci, Patrizia Tosi, Sara Mohamed, Alessandro Corso, Mario Luppi, Nicola Giuliani, Alessandro Busca, Livio Pagano, Raffaele Bruno, Paolo Antonio Grossi, Paolo Corradini, Francesco Passamonti, Luca Arcaini, on behalf of the ITA‐HEMA‐COV Investigators   +54 more
wiley   +1 more source

Incidence of post-transplant cytomegalovirus viremia in patients receiving lungs after ex vivo lung perfusionCentral MessagePerspective

JTCVS Open, 2023
Objectives: Cytomegalovirus infection after lung transplant is associated with increased morbidity and mortality. Inflammation, infection, and longer ischemic times are important risk factors for cytomegalovirus infection.
Rafaela V.P. Ribeiro, MD, PhD, Anas Samman, BSc, Aizhou Wang, PhD, Stella Wang, BSc, MSc, Tereza Martinu, MD, MHS, Shaf Keshavjee, MSc, MD, Lianne G. Singer, MD, Deepali Kumar, MSc, MD, Atul Humar, MSc, MD, Marcelo Cypel, MSc, MD   +9 more
doaj  

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Advanced Science, EarlyView.
Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope, Adam Horn, Kaitlyn Lazorchak, Clyde W. Tinnen, Jack J Stevens, Mehtab Farooqui, Tanner Robertson, Jiayi Li, David Bennin, Terry Juang, Adeel Ahmed, Chao Li, Anna Huttenlocher, David J Beebe   +13 more
wiley   +1 more source

Associations between early‐life and in utero infections and cytomegalovirus‐positive acute lymphoblastic leukemia in children

International Journal of Cancer, Volume 152, Issue 5, Page 845-853, 1 March 2023., 2023
What's new? Cytomegalovirus (CMV) infection early in life likely contributes to the development of childhood acute lymphoblastic leukemia (ALL), owing to CMV‐induced alterations in immune function. In the present study, the relationship between risk of childhood ALL and exposure to CMV in utero or early life was investigated among children with ALL who
Rachel E. Gallant, Katti Arroyo, Catherine Metayer, Alice Y. Kang, Adam J. de Smith, Joseph L. Wiemels   +5 more
wiley   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

A diagnostic study of the causes of abortion parasitic and viral in women in Kirkuk city [PDF]

Kirkuk Journal of Science, 2016
310 serum samples collected for women audits to Kirkuk General Hospital in Kirkuk city suspected of toxoplasmosis(TOXO), Cytomegalovirus(CMV), Rubella virus(RV) and Herpes virus II (HSV).
Bafreen M. Raza, Sadia Sh. Hamad
doaj   +1 more source