Results 241 to 250 of about 3,288,372 (337)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome.

Journal of Neurology Neurosurgery & Psychiatry, 1997
B. Jacobs, P. A. van, Doom, J. Groeneveld, A. Tio‐Gillen, F. V. D. Meché   +5 more
semanticscholar   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source

THE EFFECT OF CYTOMEGALOVIRUS INFECTION ON THE HOST RESPONSE TO FOREIGN AND HAPTEN-MODIFIED SELF HISTOCOMPATIBILITY ANTIGENS

, 1984
Jane E. Grundy, Gene M. Shearer
openalex   +1 more source

Population Pharmacokinetics and Exposure–Response Relationships of Maribavir in Transplant Recipients With First Episode or Refractory Cytomegalovirus

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Maribavir's anti‐cytomegalovirus (CMV) activity and favorable safety/tolerability profile is a welcomed addition to the CMV treatment armamentarium. To further characterize pharmacokinetic (PK) and exposure–response relationships of maribavir in transplant recipients with CMV, a population PK model was updated with data from the AURORA study ...
Kefeng Sun, Claudia Jomphe, Nathalie H. Gosselin, Leon Pheng, Chandrasekar Durairaj, Yaming Hang, Indranil Bhattacharya   +6 more
wiley   +1 more source

State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna, Amitava Mitra, Matthew L. Zierhut, Lilly East, Chandra Durairaj   +4 more
wiley   +1 more source

Dihydrotanshinone I Targets PGAM1 to Induce SYVN1‐Mediated Ubiquitination and Suppress Glycolysis in Hepatocellular Carcinoma

Phytotherapy Research, EarlyView.
DHT Induced SYVN1‐Mediated PGAM1 Degradation Blocks HCC Glycolysis. ABSTRACT Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme frequently overexpressed in hepatocellular carcinoma (HCC), contributing to tumor progression through aberrant glycolysis.
Ru Xu, Jiawei Dai, Ruijie Gong, Ruoxin Tu, Qiaozi Wang, Hongdan Zheng, Li Zhou, Shusheng Wang, Jiabin Cai, Haixiang Sun, Pingting Gao, Pengfei Gao   +11 more
wiley   +1 more source

Human Cytomegalovirus and Monocytes: Limited Infection and Negligible Immunosuppression in Normal Mononuclear Cells Infected in vitro with Mycoplasma-free Virus Strains

, 1989
Diane Scott, Brian Rodgers, C. A. Freeke, J. Buiter, J. G. P. Sissons   +4 more
openalex   +1 more source

Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes

Small Methods, EarlyView.
This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang, Taesoo Kim, Su‐jin Hong, Se‐yeon Kim, Hyeseung Hwang, Siwon Kim, Su‐a Kang, Nabin Won, Dogeun Kim, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Kyubong Jo, Kwang‐il Lim   +13 more
wiley   +1 more source