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Cytomegalovirus Retinitis in infancy [PDF]

Eye, 2004
To describe the presentation of cytomegalovirus retinitis (CMVR) in a series of infants.Immunocompromised infants with either HIV or systemic cytomegalovirus (CMV) were examined for CMVR. Ocular involvement was recorded and monitored by digital imaging.Five infants were detected to have CMVR. All the infants demonstrated changes within the macula.
S M E, Wren, A R, Fielder, D, Bethell, E G H, Lyall, G, Tudor-Williams, K D, Cocker, S M, Mitchell   +6 more
openaire   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Smart Polymer‐Based Drug Delivery Systems for Managing Infective Conjunctivitis: Advances and Future Prospects

Nano Select, Volume 7, Issue 6, June 2026.
The introduction covers the background and significance of conjunctivitis. It continues with a review of etiology, epidemiology, and clinical manifestations. Diagnostic methods are described, followed by discussions on pathophysiology and classification. Current treatment strategies, preventive measures, and therapeutic challenges are analyzed.
Xia Linkang, Marwan Abdelmahmoud Abdelkarim Maki, Saad Tayyab, Sachin Thakur, Pankaj Kumar, Ritu Karwasra, Mahesh Harihar Behare, Nitin Sharma, Wan Hamirul Bahrin Wan Kamal, Oganeswary Kobi, Kushagra Khanna, Mogana Rajagopal   +11 more
wiley   +1 more source

An Evaluation of Foreign Clinical Data in the Approval Reviews of Antimicrobial Medicines in Japan: Considering Ethnic and Regional Differences in Data Extrapolations in Accordance With Regulatory Circumstances

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The approval requirements in new regions that do not require domestic clinical data and the clinical data evaluation of multi‐regional clinical trials (MRCTs) and foreign clinical trials (FCTs) in the Japanese approval review processes for antimicrobial medicines were explored.
Rumiko Shimazawa, Masayuki Ikeda
wiley   +1 more source

Serological screening for cytomegalovirus in a leucodepleted blood supply: A systematic review

Vox Sanguinis, Volume 121, Issue 6, Page 722-731, June 2026.
Abstract Background and Objectives Cytomegalovirus (CMV) causes harm in at‐risk populations. Selection of seronegative donors has been used to prevent transmission. Leucodepletion reduces the potential for CMV transmission; however, the residual risk is uncertain, leading to variability in practice.
Philip J. Crispin, Danielle Edwards, Karen Beattie, Kristen Brown, Lisa Clarke, Fiona King, Amanda Ormerod, Bryony Ross   +7 more
wiley   +1 more source

Artifact‐Minimizing Ultrathin Transparent Electrodes Fabricated via iCVD for In Vivo Optogenetic Stimulation and Neural Signal Monitoring of Primary Visual Cortex

Advanced Functional Materials, Volume 36, Issue 42, 26 May 2026.
We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun, Minju Kim, Chaesung Kim, Yunyoung Choi, In‐Yeop Baek, Younghak Cho, Gyeongyong Lee, Yerim Jang, Min‐Ho Nam, Wonryung Lee, Maesoon Im, Hyejeong Seong   +11 more
wiley   +1 more source

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source

Tuberculous Endophthalmitis With Phthisis Bulbi: A Diagnostic Delay Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Tuberculous endophthalmitis should be prioritized in differential diagnosis for unexplained endophthalmitis in TB‐endemic regions; early systemic evaluation, timely pars plana vitrectomy, and adjunctive corticosteroids are crucial to prevent phthisis bulbi, though evidence for some interventions remains limited.
Yanchen Chen, Shengnan Li, Xin Chen, Ningpu Liu, Dongjing Liu   +4 more
wiley   +1 more source

A novel case of autosomal recessive CARD11 loss‐of‐function underlying impaired antiviral immunity and a review of literature

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
We report on a patient homozygous for a novel autosomal recessive loss‐of‐function CARD11 variant, with susceptibility to live attenuated virus (LAV) vaccines and impaired clearance of multiple naturally acquired respiratory viral infections. Inborn errors of immunity affecting the CARD11‐BCL10‐MALT1 (CBM) complex should be considered in individuals ...
Hamish Anderson, Cecilia Verryt, Paula Keating, Thomas Saunders, Samuel Dalton, Barry D Hock, Liping Goddard, Kylie Drake, Anja Werno, John O'Donnell, Jeffrey R Stinson, Andrew L Snow, Kuang‐Chih Hsiao   +12 more
wiley   +1 more source