Results 1 to 10 of about 97,070 (176)

A trans-activating transduction peptide fused nanobody targeting viral nonstructural protein NS4B inhibits bovine viral diarrhea virus replication. [PDF]

Front Immunol
Introduction Bovine viral diarrhea virus (BVDV) is a major pathogen in cattle globally. Nanobodies (Nbs) possess attractive therapeutic properties, but their efficacy against intracellular targets like BVDV is hindered by poor membrane permeability ...
Zhao B, Lv Z, Fan W, Zhang Y, Wei S, Fang J, Huang N, Chen X, Wang L, Qi X.   +9 more
europepmc   +2 more sources

Serosurvey of Bovine Viral Diarrhea Virus in Cattle in Southern Japan and Estimation of Its Transmissibility by Transient Infection in Nonvaccinated Cattle. [PDF]

Viruses
Bovine viral diarrhea (BVD) is caused by the BVD virus (BVDV) and has been reported worldwide in cattle. To estimate BVDV circulation among cattle where few BVD cases were reported in southern Japan, 1910 serum samples collected from 35 cattle farms ...
Isoda N, Sekiguchi S, Ryu C, Notsu K, Kobayashi M, Hamaguchi K, Hiono T, Ushitani Y, Sakoda Y.   +8 more
europepmc   +2 more sources

Novel Cost-Efficient Graphene-Based Impedance Biosensor for the Analysis of Viral Cytopathogenicity and the Effect of Antiviral Drugs [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Biosensors become increasingly relevant for medical diagnostics, pharmaceutical industry, and environmental technology, for example, to test new drugs easily and reliably or to detect cell growth in changing environmental conditions. Novel materials like graphene are promising candidates to produce biosensors on an industrial scale by means of printing
Schultz, Anke, Knoll, Thorsten, Urban, Andreas, Schuck, Herbert, von Briesen, Hagen, Germann, Anja, Velten, Thomas   +6 more
openaire   +4 more sources

Possibilities of suppressing the cytopathogenic effect of SARS-CoV-2 coronavirus according to the results of the antiviral activity of Cytovir®-3 in vitro study

Antibiotics and Chemotherapy, 2021
Introduction. The COVID-19 pandemic has stimulated the search for drugs with specific antiviral activity against the new pathogenic strain of the SARS-CoV-2 coronavirus. First of all, scientific search was aimed at studying drugs with already proven efficacy
V. Smirnov, I. Leneva, T. A. Kudryavtseva, E. B. Fayzuloev, V. Zaplutanov, S. Petlenko, N. Kartashova, A. Gracheva, E. Korchevaya   +8 more
semanticscholar   +1 more source

Antiviral Effect of Cerium Dioxide Nanoparticles on the Model of the Causative Agent of Bovine Viral Diarrhea

Mikrobiolohichnyi zhurnal, 2021
Cerium dioxide nanoparticles (CeO2) have a wide range of biological properties, including antiviral activity. Preparations based on cerium oxide nanoparticles can be effective against animal RNA viruses, which have the greatest epizootic significance for
B. Stegniy, O. A. Demchenko, O. Korneykov, M. Stegniy, A. Oleshko, O.B. Korneikova, I. V. Korovin, L. Babenko, M. Spivak   +8 more
semanticscholar   +1 more source

Experimental Justification of Reprofiling of the Drug Maxar® for the Treatment of Viral Infections

Antibiotics and Chemotherapy, 2023
Relevance. The development of highly effective broad-spectrum antiviral agents is one of the priorities in medicine, virology, and pharmacology. The strategy of repurposing (repositioning) registered drugs is of special interest along with significant ...
T. Zaporozhets, N. V. Krylova, S. Fedoreyev, O. V. Iunikhina, A. B. Pott, D. Tarbeeva, N. Mishchenko, M. Shchelkanov   +7 more
semanticscholar   +1 more source

Chios mastic gum inhibits influenza A virus replication and viral pathogenicity.

Journal of General Virology, 2021
Chios mastic gum (CMG), a resin of the mastic tree (Pistacia lentiscus var. chia), has been used to treat multiple disorders caused by gastrointestinal malfunctions and bacterial infections for more than 2500 years.
Dong-in Kim, Yong-Bin Cho, Younghyun Lim, So-Hee Hong, B. Hahm, Sang‐Myeong Lee, S. Kang, Y. Seo   +7 more
semanticscholar   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +2 more sources

Deficiency of immunity to poliovirus type 3: a lurking danger? [PDF]

, 2012
Background: Europe was certified to be polio-free in 2002 by the WHO. However, wild polioviruses remain endemic in India, Pakistan, Afghanistan, and Nigeria, occasionally causing polio outbreaks, as in Tajikistan in 2010.
Doerr, Hans W., Friedrichs, Imke, Rabenau, Holger, Reinheimer, Claudia   +3 more
core   +2 more sources

RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux

Cell Death and Disease, 2019
Early detection of viruses by the innate immune system is crucial for host defense. The NLRP3 inflammasome, through activation of caspase-1, promotes the maturation of IL-1β and IL-18, which are critical for antiviral immunity and inflammatory response ...
Leandro Silva da Costa, Ahmed Outlioua, A. Anginot, K. Akarid, D. Arnoult   +4 more
semanticscholar   +1 more source