Results 91 to 100 of about 1,300,822 (378)

Threshold estimation based on local minima for nucleus and cytoplasm segmentation

BMC Medical Imaging, 2022
Background Image segmentation is the process of partitioning an image into separate objects or regions. It is an essential step in image processing to segment the regions of interest for further processing.
Simeon Mayala, Jonas Bull Haugsøen
doaj   +1 more source

Efficient expression of full-length antibodies in the cytoplasm of engineered bacteria

Nature Communications, 2015
Current methods for producing immunoglobulin G (IgG) antibodies in engineered cells often require refolding steps or secretion across one or more biological membranes.
Michael-Paul Robinson, N. Ke, J. Lobstein, Cristen B. Peterson, A. Szkodny, T. Mansell, Corinna Tuckey, P. Riggs, P. Colussi, C. Noren, C. Taron, M. DeLisa, M. Berkmen   +12 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Automatic recognition of acute myelogenous leukemia in blood microscopic images using K-means clustering and support vector machine

Journal of Medical Signals and Sensors, 2016
Acute myelogenous leukemia (AML) is a subtype of acute leukemia, which is characterized by the accumulation of myeloid blasts in the bone marrow. Careful microscopic examination of stained blood smear or bone marrow aspirate is still the most significant
Fatemeh Kazemi, Tooraj Abbasian Najafabadi, Babak Nadjar Araabi   +2 more
doaj  

Sex-specific alterations in creatine metabolism in cellular compartments of peripheral blood leukocytes in type 1 diabetes

AIMS Bioengineering
The creatine (Cr)/creatine kinase (CK) system plays a crucial role in cellular energy metabolism, glucose control, and the immune response. This study aimed to investigate this system in the peripheral blood leukocytes (PBL) of Armenians with type 1 ...
Nina Alchujyan, Elena Aghajanova, Nina Movsesyan, Arthur Melkonyan, Artashes Guevorkian, Armen Andreasyan, Margarita Hovhannisyan   +6 more
doaj   +1 more source

Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Hormonal and nutrient signals regulate leptin synthesis and secretion. In rodents, leptin is stored in cytosolic pools of adipocytes. However, not much information is available regarding the regulation of intracellular leptin in ruminants.
Shinichi Yonekura, Shohei Hirota, Yukako Tokutake, Michael T. Rose, Kazuo Katoh, Hisashi Aso   +5 more
doaj   +1 more source

Targeting antibodies to the cytoplasm [PDF]

mAbs, 2011
A growing number of research consortia are now focused on generating antibodies and recombinant antibody fragments that target the human proteome. A particularly valuable application for these binding molecules would be their use inside a living cell, e.g., for imaging or functional intervention.
Thomas Schirrmann, Stefan Dübel, Andrea L. J. Marschall, Manuela Schüngel, André Frenzel   +4 more
openaire   +3 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]

, 1990
In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias, Sangiorgi, Frank, Woods, Catherine M.   +2 more
core  

NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection. [PDF]

, 2014
Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination.
Lee, Yoo Jin, Lim, David J, Moon, Sung K, Oh, Sejo, Webster, Paul, Woo, Jeong-Im   +5 more
core   +3 more sources