Results 71 to 80 of about 17,208 (210)

A machine learning model for predicting fertilization following short‐term insemination using embryo images

Reproductive Medicine and Biology
Purpose This study established a machine learning model (MLM) trained on embryo images to predict fertilization following short‐term insemination for early rescue ICSI and compared its predictive performance with the embryologist's manual classification.
Masato Saito, Hirofumi Haraguchi, Ikumi Nakajima, Shinya Fukuda, Chenghua Zhu, Norio Masuya, Kazunori Matsumoto, Yuya Yoshikawa, Tomoki Tanaka, Satoshi Kishigami, Leona Matsumoto   +10 more
doaj   +1 more source

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

eLife
Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes 1 (NPR1) acts as a signaling hub of plant immunity. However, the relationship between ATG6 and NPR1 is unclear.
Baihong Zhang, Shuqin Huang, Shuyu Guo, Yixuan Meng, Yuzhen Tian, Yue Zhou, Hang Chen, Xue Li, Jun Zhou, Wenli Chen   +9 more
doaj   +1 more source

Fractal organization of feline oocyte cytoplasm

European Journal of Histochemistry, 2009
The present study aimed at verifying whether immature cat oocytes with morphologic irregular cytoplasm display selfsimilar features which can be analytically described by fractal analysis. Original images of oocytes collected by ovariectomy were acquired
G De Vico, V Peretti, GA Losa
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Protein diffusion in mammalian cell cytoplasm.

PLoS ONE, 2011
We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell. This method is based on the construction of a three-dimensional digital model cell from confocal microscopy data.
Thomas Kühn, Teemu O Ihalainen, Jari Hyväluoma, Nicolas Dross, Sami F Willman, Jörg Langowski, Maija Vihinen-Ranta, Jussi Timonen   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Long Non-coding RNAs in the Cytoplasm

Genomics, Proteomics & Bioinformatics, 2016
An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs.
Farooq Rashid, Abdullah Shah, Ge Shan
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Editorial: pH as a signal and secondary messenger in plant cells

Frontiers in Plant Science, 2023
Agepati S. Raghavendra, Wenxiu Ye, Toshinori Kinoshita   +2 more
doaj   +1 more source