Results 91 to 100 of about 1,366,500 (340)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Automatic recognition of acute myelogenous leukemia in blood microscopic images using K-means clustering and support vector machine

Journal of Medical Signals and Sensors, 2016
Acute myelogenous leukemia (AML) is a subtype of acute leukemia, which is characterized by the accumulation of myeloid blasts in the bone marrow. Careful microscopic examination of stained blood smear or bone marrow aspirate is still the most significant
Fatemeh Kazemi, Tooraj Abbasian Najafabadi, Babak Nadjar Araabi   +2 more
doaj  

Dissecting the disconnect between circuit activation and dominant adaptive evolution in cytoplasmic phage-assisted continuous evolution (PACE) of an EGFR nanobody

Frontiers in Bioengineering and Biotechnology
IntroductionCytoplasmic phage-assisted continuous evolution (PACE) is widely used due to its low selection pressure and straightforward circuit design.
Jie-Ning Chuang, Jacob Purcell, Loki Sangalli, Joseph Rosenbluh, Gavin J. Knott, Gavin J. Knott, Simon Corrie, Gil Garnier   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning

, 2021
Cells are filled with macromolecules and polymer networks that set scale-dependent viscous and elastic properties to the cytoplasm. Although the role of these parameters in molecular diffusion, reaction kinetics, and cellular biochemistry is being ...
Xie, Jing, Borgne, Rémi Le, Minc, Nicolas, Le Borgne, Rémi, Sallé, Jeremy, Verbavatz, Jean-Marc, Durieu, Catherine, Najafi, Javad   +7 more
core   +1 more source

Fatal and Benign Congenital Myopathies: Differential Diagnosis

Pediatric Neurology Briefs, 1991
Muscle biopsies from four infants with fatal myopathy and four with benign myopathy were examined using biochemical, histochemical and immunohistochemical techniques in the Departments of Neurology, Pathology and Genetics, Columbia University, New York ...
J Gordon Millichap
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Anti-neutrophil cytoplasm-associated glomerulonephritis.

, 2006
Wegener's granulomatosis, microscopic polyangiitis, and renal limited vasculitis are associated with circulating anti-neutrophil cytoplasm antibodies and are an important cause of rapidly progressive glomerulonephritis.
Julie Williams, Morgan, Matthew, Savage, Caroline, Matthew David Morgan, Williams, Julie, Lorraine Harper, Caroline Savage, Harper, Lorraine   +7 more
core   +1 more source

The Whereabouts of miRNA Actions: Cytoplasm and Beyond

Trends in Cell Biology, 2015
miRNAs are a conserved class of approximately 22 nucleotide (nt) short non-coding RNAs that normally silence gene expression via translational repression and/or degradation of targeted mRNAs in plants and animals.
A. Leung
semanticscholar   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source