Results 101 to 110 of about 1,366,500 (340)

A machine learning model for predicting fertilization following short‐term insemination using embryo images

Reproductive Medicine and Biology
Purpose This study established a machine learning model (MLM) trained on embryo images to predict fertilization following short‐term insemination for early rescue ICSI and compared its predictive performance with the embryologist's manual classification.
Masato Saito, Hirofumi Haraguchi, Ikumi Nakajima, Shinya Fukuda, Chenghua Zhu, Norio Masuya, Kazunori Matsumoto, Yuya Yoshikawa, Tomoki Tanaka, Satoshi Kishigami, Leona Matsumoto   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Garlic virus X 11-kDa protein granules move within the cytoplasm and traffic a host protein normally found in the nucleolus [PDF]

, 2011
The subcellular localization of the 11-kDa protein (p11) encoded by ORF3 of Garlic virus X (GarVX; genus Allexivirus, family Alphaflexiviridae) was examined by confocal microscopy.
Yan, F., Chen, J., Adams, M. J., Lu, Y., Zheng, H., Guo, W., Lin, L., Peng, J.   +7 more
core   +1 more source

Cytoplasmic domains in eggs [PDF]

Trends in Cell Biology, 1994
One way of organizing the body plan of a developing embryo is to establish domains in the egg with distinct compositions in defined spatial relationships to one another: when the egg divides up, these domains segregate preferentially to certain regions of the embryo and influence their development.
Sardet, Christian, Mcdougall, Alex, Houliston, Evelyn   +2 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Merging mitochondria into cytoplasm.

, 2015
The figure shows mitochondria superpixels absorbed into cytoplasm superpixels up to different values of overlap ratio ρ(Sm, Sc)
Louis Scheffer (746020), Anirban Chakraborty (67617), Stephen Plaza (746019), Toufiq Parag (448176)   +3 more
core   +1 more source

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

Nature Chemistry, 2013
Following extensive evidence for the formation of four-stranded DNA G-quadruplex structures in vitro, DNA G-quadruplexes have been observed within human cells. Although chemically distinct, RNA can also fold in vitro into G-quadruplex structures that are
Giulia Biffi, M. Di Antonio, D. Tannahill, S. Balasubramanian   +3 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Protein dynamics under crowding

Advances in Physics: X
Protein dynamics in cells are essential for metabolic processes that rely on protein encounter and transport. In order to understand this process, namely, the impact of the crowding nature of the cytoplasmic space, advanced ensemble and single-molecule ...
Beatrice Caviglia, Valeria Libera, Judith Peters, Alessandro Paciaroni, Fabio Sterpone   +4 more
doaj   +1 more source