Results 111 to 120 of about 299,119 (223)
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]
, 2015 The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair +63 more
core +3 more sources
Nuclear migration: Cortical anchors for cytoplasmic dynein [PDF]
Current Biology, 2001 Nuclear migration in yeast provides a model system for studying how a cell polarizes the actin and microtubule cytoskeletons toward sites of cell growth. Recent findings indicate that cortical anchors are necessary for directing microtubule-based processes.
openaire +2 more sources
Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes
Protein Science, Volume 35, Issue 5, May 2026.Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni +9 more
wiley +1 more source
Molecular motors: design, mechanism and control
, 2008 Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which synthesize ...
Chowdhury, Debashish
core +1 more source
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte
Journal of Cell Biology, 1994 The unidirectional movements of the microtubule-associated motors, dyneins, and kinesins, provide an important mechanism for the positioning of cellular organelles and molecules.
Mingang Li +3 more
semanticscholar +1 more source
Mitochondrial Transfer in the Tumor Microenvironment
Cancer Science, Volume 117, Issue 5, Page 1189-1198, May 2026.Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae +2 more
wiley +1 more source
Journal of Cell Biology, 1992 We report here the cloning and sequencing of a cytoplasmic dynein heavy chain gene from the cellular slime mold Dictyostelium discoideum. Using a combination of approaches, we have isolated 14,318 bp of DNA sequence which contains an open-reading frame ...
M. Koonce, P. Grissom, J. Mcintosh
semanticscholar +1 more source
Energetic costs, precision, and efficiency of a biological motor in cargo transport
, 2018 Molecular motors play pivotal roles in organizing the interior of cells. A motor efficient in cargo transport would move along cytoskeletal filaments with a high speed and a minimal error in transport distance (or time) while consuming a minimal amount ...
Hwang, Wonseok, Hyeon, Changbong
core +1 more source
Gene knockouts reveal separate functions for two cytoplasmic dyneins in Tetrahymena thermophila.
Molecular Biology of the Cell, 1999 Seungwon Lee +3 more
semanticscholar +1 more source