Results 91 to 100 of about 299,119 (223)

Transport by molecular motors in the presence of static defects [PDF]

, 2009
The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and unbinding from the
A. Ebneth, A. Parmeggiani, A. Seitz, A. Seitz, A.B. Kolomeisky, B. Schmittmann, B.M. Paschal, C. Leduc, E.-M. Mandelkow, G. Tripathy, G.A. Klein, G.M. Schütz, H. Hagiwara, H. Hess, I.M. Crevel, J. Beeg, J. Howard, J. Krug, J.-C. Larcher, J.C. Bulisnki, K. Nishinari, K. Tokuraku, L.A. Lopez, L.J. Davis, L.S.B. Goldstein, M. Vershinin, M. Vershinin, M.G.L. Heuvel Van den, M.J.I. Müller, M.J.I. Müller, M.R. Evans, N. Mirin, N.A. Reed, P. Pierobon, R. Dixit, R. Lipowsky, R. Lipowsky, R. Sato-Harada, Reinhard Lipowsky, S. Heins, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Konzack, S. Lakämper, S.A. Janowsky, Stefan Klumpp, T.M. Nieuwenhuizen, Yan Chai   +52 more
core   +3 more sources

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport [PDF]

, 2015
Dynein-dependent transport of organelles from the axon terminals to the cell bodies is essential to the survival and function of neurons. However, quantitative knowledge of dyneins on axonal organelles and their collective function during this long ...
Bawendi, Moungi G., Che, Daphne L., Chen, Ou, Chowdary, Praveen D., Cui, Bianxiao, Kaplan, Luke, Pu, Kanyi   +6 more
core   +1 more source

Bidirectional helical motility of cytoplasmic dynein around microtubules [PDF]

eLife, 2014
Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo transport along microtubules (MTs). Dynein motility has previously been studied on surface-immobilized MTs in vitro, which constrains the motors to move in two dimensions. In this study, we explored dynein motility in three dimensions using an MT bridge assay.
Can, Sinan, Dewitt, Mark A, Yildiz, Ahmet   +2 more
openaire   +5 more sources

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, EarlyView.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

Anaphase B. [PDF]

, 2016
Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Brust-Mascher, Ingrid, Civelekoglu-Scholey, Gul, Scholey, Jonathan M   +2 more
core   +2 more sources

A cytoplasmic dynein tail mutation impairs motor processivity [PDF]

Nature Cell Biology, 2010
Mutations in the tail of the cytoplasmic dynein molecule have been reported to cause neurodegenerative disease in mice. The mutant mouse strain Legs at odd angles (Loa) has impaired retrograde axonal transport, but the molecular deficiencies in the mutant dynein molecule, and how they contribute to neurodegeneration, are unknown.
Ori-McKenney, Kassandra M., Xu, Jing, Gross, Steven P., Vallee, Richard B.   +3 more
openaire   +2 more sources

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action [PDF]

, 2017
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-
Asano, Moriteru, Aso, Kazuyoshi, Carter, Andrew P., Chen, James K., Foley, Michael A., Fukase, Yoshiyuki, Furukawa, Hideki, Gelfand, Vladimir I., Johnson, Alex G., Kapoor, Tarun M., Miller, Rand M., Morimoto, Sachie, Nachury, Maxence V., Nishitani, Mitsuyoshi, Ondrus, Alison E., Santarossa, Cristina C., Serpinskaya, Anna S., Steinman, Jonathan B., Tanaka, Yuta, Ye, Fan, Yu, Lola S., Zalyte, Ruta   +21 more
core  

General theory for the mechanics of confined microtubule asters [PDF]

, 2014
In cells, dynamic microtubules organize into asters or spindles to assist positioning of organelles. Two types of forces are suggested to contribute to the positioning process: (i) microtubule-growth based pushing forces ; and (ii) motor protein mediated
Dogterom, Marileen, Jülicher, Frank, Laan, Liedewij, Ma, Rui, Pavin, Nenad   +4 more
core   +3 more sources