Results 81 to 90 of about 299,119 (223)

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Model for bidirectional movement of cytoplasmic dynein [PDF]

Journal of Theoretical Biology, 2015
Cytoplasmic dynein exhibits a directional processive movement on microtubule filaments and is known to move in steps of varying length based on the number of ATP molecules bound to it and the load that it carries. It is experimentally observed that dynein takes occasional backward steps and the frequency of such backward steps increases as the load ...
Sumathy, S., Satyanarayana, S. V. M.
openaire   +4 more sources

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Tug-of-war of molecular motors: the effects of uneven load sharing

, 2011
We analyze theoretically the problem of cargo transport along microtubules by motors of two species with opposite polarities. We consider two different one-dimensional models previously developed in the literature.
Bouzat, Sebastian, Falo, Fernando
core   +1 more source

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements [PDF]

, 2017
Cilia are multi-functional organelles that are constructed using intraflagellar transport (IFT) of cargo to and from their tip. It is widely held that the retrograde IFT motor, dynein-2, must be controlled in order to reach the ciliary tip and then ...
A Hyman, AJ Roberts, AJ Roberts, AJ Roberts, Anthony J Roberts, AP Carter, B Prevo, BD Engel, BH Gibbons, BS Goodman, C Cho, C Mencarelli, CD Albracht, CL Williams, D Asante, D Signor, DG Cole, EF Pettersen, G Piperno, GJ Pazour, GJ Pazour, H Imai, H Ishikawa, H Schmidt, H Schmidt, I Yu, IR Gibbons, J Frank, J Schindelin, JA Mindell, JL Rosenbaum, JM Scholey, JO Andreasson, KA Johnson, Katerina Toropova, KF Lechtreck, KG Kozminski, KJ Verhey, L Hao, L Stepanek, L Urnavicius, LA Amos, LB Pedersen, M Brunnbauer, M Castoldi, M Fliegauf, M Ichikawa, M Imanishi, M Schmidts, M Taschner, M Taschner, M Trokter, M van Heel, MA Cianfrocco, MA Schlager, ME Porter, Miroslav Mladenov, MP Nicholas, ND Derr, RJ McKenney, RS Patel-King, S Bhogaraju, S Chowdhury, SA Burgess, SH Scheres, SJ Ludtke, SL Reck-Peterson, SM Shih, T Kon, T Kon, T Kon, T Kon, T Kubo, T Shima, T Torisawa, TQ Uyeda, V Belyy, W Li, W Qiu, WO Hancock, Y Hou, Y Liang   +81 more
core   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Connecting two arrays: the emerging role of actin-microtubule cross-linking motor proteins [PDF]

, 2015
The cytoskeleton of plant cells, consisting of actin filaments (AFs) and microtubules (MTs), is a central structure for various intracellular processes, such as cell division, isotropic and polar growth, vesicle transport, cell shape, and morphogenesis ...
René Schneider, Staffan Persson
core   +3 more sources

Molecular mechanism of cytoplasmic dynein tension sensing [PDF]

Nature Communications, 2019
AbstractCytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein’s function is its capacity to respond anisotropically to tension, so that its microtubule-binding domains bind microtubules more strongly when under backward load than forward load.
Lu Rao, Florian Berger, Matthew P. Nicholas, Arne Gennerich   +3 more
openaire   +3 more sources

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source