Results 61 to 70 of about 299,119 (223)

Structure and Mechanics of Dynein Motors.

Annual Review of Biophysics, 2021
Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules. Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells and mediating spindle assembly and chromosome positioning during cell ...
J. Canty, Ruensern Tan, Emre Kusakci, Jonathan Fernandes, A. Yildiz   +4 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

ACS Chemical Biology, 2015
Cytoplasmic dyneins 1 and 2 are related members of the AAA+ superfamily (ATPases associated with diverse cellular activities) that function as the predominant minus-end-directed microtubule motors in eukaryotic cells.
Stephanie K. See, S. Hoogendoorn, Andrew H. Chung, Fan Ye, J. B. Steinman, Tomoyo Sakata-Kato, Randy M. Miller, T. Cupido, Ruta Zalyte, A. Carter, M. Nachury, T. Kapoor, James K. Chen   +12 more
semanticscholar   +1 more source

Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]

The Journal of Neuroscience, 2006
Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate ...
Mesngon, Mariano T., Tarricone, Cataldo, Hebbar, Sachin, Guillotte, Aimee, Schmitt, E. William, Lanier, Lorene, Musacchio, Andrea, King, Stephen J., Smith, Deanna S.   +8 more
openaire   +3 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Mechanical coupling of microtubule-dependent motor teams during peroxisome transport in Drosophila S2 cells [PDF]

, 2017
Background: Intracellular transport requires molecular motors that step alongcytoskeletal filaments actively dragging cargoes through the crowded cytoplasm.
Benseñor, Lorena, Bruno, Luciana, De Rossi, María Cecilia, De Rossi, María Emilia, Gelfand, Vladimir, Levi, Valeria, Rodríguez, Daniela, Sued, Raquel Mariela, Wetzler, Diana E.   +8 more
core   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules [PDF]

, 2015
Cytoplasmic dynein is a dimeric AAA+ motor protein that performs critical roles in eukaryotic cells by moving along microtubules using ATP. Here using cryo-electron microscopy we directly observe the structure of Dictyostelium discoideum dynein dimers on
A Gennerich, A Hyman, A Yildiz, AA Hyman, AF Neuwald, AJ Roberts, AJ Roberts, AJ Roberts, AP Carter, C Veigel, CV Sindelar, D Chrétien, D Chrétien, DJ-K Hu, EF Pettersen, FB Cleary, G Mocz, H Schmidt, H Schmidt, H Sui, H Ueno, J Eschbach, J Frank, J Lin, J Lipka, JA Mindell, JR Kardon, K Furuta, K Imamula, KMR Bhat, KS Thorn, L-L Frado, LA Amos, M Fu, MA DeWitt, MA Schlager, ML Walker, MP Nicholas, N Billington, N Hirokawa, N Numata, P Meurer-Grob, RB Vallee, RB Vallee, RD Vale, RD Vale, RJ McKenney, S Chowdhury, S Toba, SA Burgess, SA Burgess, SJ Ludtke, SL Reck-Peterson, T Kon, T Kon, T Kon, T Kon, T Movassagh, T Shima, T Shima, T Torisawa, V Belyy, W Kabsch, WB Redwine, WH Qiu, Y Nishikawa   +65 more
core   +1 more source

Cytoplasmic Dynein LC8 Interacts with Lyssavirus Phosphoprotein [PDF]

Journal of Virology, 2000
ABSTRACT Using a yeast two-hybrid human brain cDNA library screen, the cytoplasmic dynein light chain (LC8), a 10-kDa protein, was found to interact strongly with the phosphoprotein (P) of two lyssaviruses: rabies virus (genotype 1) and Mokola virus (genotype 3).
Jacob, Yves, Badrane, Hassan, Ceccaldi, Pierre-Emmanuel, Tordo, Noël   +3 more
openaire   +2 more sources

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source