Results 71 to 80 of about 299,119 (223)
Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
, 2015 Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large.
Appert-Rolland, Cecile +2 more
core +3 more sources
A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]
, 2018 Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
Hafezparast, M, Madzvamuse, A, Trott, L
core +2 more sources
PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana
Cytoskeleton, EarlyView.ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes +6 more
wiley +1 more source
Collective effects in intra-cellular molecular motor transport: coordination, cooperation and competetion [PDF]
, 2006 Molecular motors do not work in isolation {\it in-vivo}. We highlight some of the coordinations, cooperations and competitions that determine the collective properties of molecular motors in eukaryotic cells.
Chowdhury, Debashish
core +2 more sources
Cytoskeleton, EarlyView.ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source
A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein
Journal of Structural Biology, 2014 Dyneins are large protein complexes that act as microtubule based molecular motors. The dynein heavy chain contains a motor domain which is a member of the AAA+ protein family (ATPases Associated with diverse cellular Activities).
Emma S. Gleave, H. Schmidt, A. Carter
semanticscholar +1 more source
Force-Induced Bidirectional Stepping of Cytoplasmic Dynein [PDF]
Cell, 2007 Cytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of movement remains poorly understood. Here, we use optical tweezers to examine the force-dependent stepping behavior of yeast cytoplasmic dynein. We find that dynein primarily advances in 8 nm increments but takes other sized steps (4-24 nm) as well. An opposing force induces
Gennerich, Arne +3 more
openaire +2 more sources
Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium [PDF]
, 1990 Permeabilized, MgATP-reactivated cells of Paramecium (models) respond to cyclic AMP and cyclic GMP by increasing forward swimming speed. In association with the motile response, cyclic AMP and 8-bromo-cyclic GMP (8-Br-cyclic GMP) stimulated protein ...
Bonini, Nancy M., Nelson, David L.
core
The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Stephens, DJ
core +2 more sources
Reconstitution of the human cytoplasmic dynein complex [PDF]
Proceedings of the National Academy of Sciences, 2012 Cytoplasmic dynein is the major motor protein responsible for microtubule minus-end–directed movements in most eukaryotic cells. It transports a variety of cargoes and has numerous functions during spindle assembly and chromosome segregation.
Martina, Trokter +2 more
openaire +2 more sources