Results 121 to 130 of about 206,171 (265)
Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts
Angewandte Chemie, EarlyView.Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan +6 more
wiley +2 more sources
Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source
Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation
Advanced Science, EarlyView.Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir +3 more
wiley +1 more source
A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition
Advanced Science, EarlyView.These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li +7 more
wiley +1 more source
Spatiotemporal Computational Meta‐Imager for Broadband Dual‐Layer Optical Convolution
Advanced Science, EarlyView.A single‐layer polarization‐multiplexed meta‐imager achieves factorized dual‐layer broadband convolution via spatiotemporal kernel decomposition. Fixed Bessel‐vortex bases and time‐sequential liquid‐crystal modulation deliver tunable signed weights and in‐situ fabrication‐error compensation. Experiments verify improved classification performance across
Mengguang Wang +6 more
wiley +1 more source
ReLink: Reliable Deep Learning for Microscopic Motion Tracking
Advanced Science, EarlyView.ReLink enables reliable trajectory linking in single‐particle tracking by integrating physics‐informed motion statistics with confidence‐based adaptive filtering. Across diverse simulated and experimental conditions, ReLink robustly reconstructs trajectories and preserves the fidelity of downstream analyses, enabling accurate characterization of ...
Yuan Jiang +7 more
wiley +1 more source
Wolbachia infections and the expression of cytoplasmic incompatibility in Drosophila sechellia and D. mauritiana [PDF]
, 1995 Various stocks of Drosophila mauritiana and D. sechellia were found to be infected with Wolbachia, a Rickettsia-like bacterium that is known to cause cytoplasmic incompatibility and other reproductive abnormalities in arthropods.
Robertson, Hugh M. +2 more
core
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source
A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Most pathogenic tubulin variants arise de novo in sporadic patients, causing severe brain malformations and significant neurodevelopmental impairment. The resulting reproductive disadvantage typically prevents these mutations from being transmitted to offspring.
Elena Cellini +9 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Sharks possess varied diets and different prey capture mechanisms. As a result, the group exhibits a significant diversity in dental morphology, also reflecting the internal structures of the teeth. Internal dental anatomy points to the existence of three histotypes in elasmobranch phylogeny: orthodont, osteodont, and pseudoosteodont ...
Kelly Roberta da Silva +2 more
wiley +1 more source