Results 101 to 110 of about 9,534 (270)
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Wolbachia-mediated reproductive manipulation in rice planthoppers
Crop HealthRice planthoppers, including brown (Nilaparvata lugens), small brown (Laodelphax striatellus), and white-backed (Sogatella furcifera) planthoppers, are major agricultural pests in China and severely affect rice production and food security.
Yue-Di Niu +4 more
doaj +1 more source
Matrix Stiffness Induces Endothelial Network Senescence
Advanced Science, EarlyView.Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song +6 more
wiley +1 more source
A valine to leucine mutation in hypomorphic Wolbachia CidB reduces both deubiquitylation and cytoplasmic incompatibility [PDF]
, 2021 Cytoplasmic incompatibility (CI) remains one of the most highly researched and applied phenotype conferred by the bacterium, Wolbachia on the host organisms it infects.
Akwa, Daniel
core
Advanced Science, EarlyView.Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen +10 more
wiley +1 more source
Wolbachia infections and the expression of cytoplasmic incompatibility in Drosophila sechellia and D. mauritiana [PDF]
, 1995 Various stocks of Drosophila mauritiana and D. sechellia were found to be infected with Wolbachia, a Rickettsia-like bacterium that is known to cause cytoplasmic incompatibility and other reproductive abnormalities in arthropods.
Robertson, Hugh M. +2 more
core
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Wolbachia: A biological control strategy against arboviral diseases
Journal of Vector Borne Diseases, 2016 Vector-borne diseases particularly those transmitted by mosquitoes like Dengue are among the leading causes of mortality and morbidity in human population.
Ipsita Mohanty +3 more
doaj
Advanced Science, EarlyView.Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang +9 more
wiley +1 more source
Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family [PDF]
, 2009 In fungi, vegetative incompatibility is a conspecific non-self recognition mechanism that restricts formation of viable heterokaryons when incompatible alleles of specific het loci interact.
Debets, A. +6 more
core +1 more source