Results 81 to 90 of about 9,534 (270)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Wolbachia infection in Cotesia sesamiae (Hymenoptera: Braconidae) causes cytoplasmic incompatibility : implications for biological control [PDF]

, 2002
Cotesia sesamiae (Hymenoptera: Braconidae) is an indigenous, gregarious, larval endoparasitoid that attacks mid- to late-instar of the stem borer larvae. Although the parasitoid is distributed widely throughout Africa, not all local populations appear to
Stouthamer, R., Overholt, W.A., Mochiah, M.B., Ngi-Song, A.J.   +3 more
core   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia

Nature Communications, 2018
Wolbachia causes cytoplasmic incompatibility (CI) between mosquitoes infected with different strains, but the genetic basis of observed CI diversity is unknown. Here, Bonneau et al.
Manon Bonneau, Celestine Atyame, Marwa Beji, Fabienne Justy, Martin Cohen-Gonsaud, Mathieu Sicard, Mylène Weill   +6 more
doaj   +1 more source

Effects of Tetracycline and Temperature on Drosophila melanogaster Infected with Wolbachia Inducing the Popcorn-Effect

Microbiology Indonesia, 2012
The expression of cytoplasmic incompatibility, parthenogenesis, and feminization in many hosts of Wolbachia is influenced by environmental factors such as temperature and antibiotics. Therefore, it might also affect Wolbachia inducing popcorn-effect.
ENDANG SRIMURNI KUSMINTARSIH
doaj   +1 more source

Wolbachia stimulates immune gene expression and inhibits Plasmodium development in Anopheles gambia [PDF]

, 2010
The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes.
Godfray, HCJ, Sinkins, Steven P., H. Charles J. Godfray, Godfray, H. Charles J., Sinden, Robert E., Marcus S. C. Blagrove, Kambris, Zakaria, Blagrove, Marcus S. C., Andrew M Blagborough, H Charles J Godfray, Steven P Sinkins, Marcus S C Blagrove, Andrew M. Blagborough, Godfray, HC, Sinden, Robert, Blagborough, Andrew M., Blagborough, AM, Blagrove, Marcus S.C., Blagrove, MSC, Sofia B. Pinto, Sofia B Pinto, Kambris Zakaria, Robert E. Sinden, Blagrove, MS, Zakaria Kambris, Pinto, Sofia B., Blagrove Marcus S. C., Kambris, Z, Sinden Robert E., Sinden, RE, Godfray H. Charles J., Sinkins Steven P., Steven P. Sinkins, Pinto Sofia B., Sinkins, SP, Pinto, SB, Robert E Sinden, Blagborough Andrew M.   +37 more
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Asymmetrical reinforcement and Wolbachia infection in Drosophila. [PDF]

PLoS Biology, 2006
Reinforcement refers to the evolution of increased mating discrimination against heterospecific individuals in zones of geographic overlap and can be considered a final stage in the speciation process. One the factors that may affect reinforcement is the
John Jaenike, Kelly A Dyer, Chad Cornish, Miranda S Minhas   +3 more
doaj   +1 more source

Genetic and Molecular Genetic Studies in the Cytoplasmic Incompatibility System in the Mosquito Culex Pipiens. [PDF]

, 1981
An analysis of the cytoplasmic incompatibility system in Culex pipiens has been made. Both normal and antibiotic-resistant strains have been established using erythromycin, chloramphenicol and tetracycline. A complete genetic analysis has been made using
Mcgee, David Ray
core   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source