Results 231 to 240 of about 39,037 (343)

SIRT1 Prevents Lens Epithelial Cell Senescence During Age‐Related Cataract via Regulating p66Shc

open access: yesAging Cell, EarlyView.
Schematic illustration of NMN‐mediated alleviation of age‐related cataract via SIRT1/p66Shc pathway–dependent inhibition of mitochondrial dysfunction and LEC senescence. ABSTRACT Lens epithelial cell (LEC) senescence is one of the key pathological processes of age‐related cataract (ARC) and is associated with oxidative stress, mitochondrial dysfunction,
Huirui Liu   +8 more
wiley   +1 more source

Study of Cytoplasmic Male Sterility in Lentil [PDF]

open access: yes, 1982
Frederick J. Muehlbauer J.   +1 more
openaire   +2 more sources

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

open access: yesAging Cell, EarlyView.
In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu   +8 more
wiley   +1 more source

Benchmarks defining high‐quality sperm in the common marmoset (Callithrix jacchus)

open access: yesAndrology, EarlyView.
Abstract Background Common marmosets (Callithrix jacchus) are increasingly recognized as valuable nonhuman primates (NHPs) for biomedical research due to their small size and short reproductive cycle and lifespan relative to other NHP species. Maximizing the utility of captive research marmosets, including genetically manipulated animals, will require ...
Niloofar Sadeghi   +4 more
wiley   +1 more source

A novel mitochondrial orf147 causes cytoplasmic male sterility in pigeonpea by modulating aberrant anther dehiscence

open access: yesPlant Molecular Biology, 2018
P. Bhatnagar-Mathur   +7 more
semanticscholar   +1 more source

Dexamethasone is a regulator of clock genes in testicular peritubular cells

open access: yesAndrology, EarlyView.
Abstract Background We recently found that peritubular cells of the human testis are a dominant site of expression of the glucocorticoid receptor (GR; encoded by NR3C1). Activation of GR by dexamethasone (Dex) strongly influences the phenotype of cultured human testicular peritubular cells (HTPCs), causing massive changes of their proteome and ...
Harald Welter   +11 more
wiley   +1 more source

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