SIRT1 Prevents Lens Epithelial Cell Senescence During Age‐Related Cataract via Regulating p66Shc
Schematic illustration of NMN‐mediated alleviation of age‐related cataract via SIRT1/p66Shc pathway–dependent inhibition of mitochondrial dysfunction and LEC senescence. ABSTRACT Lens epithelial cell (LEC) senescence is one of the key pathological processes of age‐related cataract (ARC) and is associated with oxidative stress, mitochondrial dysfunction,
Huirui Liu+8 more
wiley +1 more source
Comparative mitochondrial genome analysis reveals a candidate ORF for cytoplasmic male sterility in tropical onion. [PDF]
Bishnoi R+6 more
europepmc +1 more source
Study of Cytoplasmic Male Sterility in Lentil [PDF]
Frederick J. Muehlbauer J.+1 more
openaire +2 more sources
In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu+8 more
wiley +1 more source
Complete Plastid and Mitochondrial Genomes of Aeginetia indica Reveal Intracellular Gene Transfer (IGT), Horizontal Gene Transfer (HGT), and Cytoplasmic Male Sterility (CMS). [PDF]
Choi KS, Park S.
europepmc +1 more source
Intraspecific variation in mitochondrial genome sequence, structure, and gene content in Silene vulgaris, an angiosperm with pervasive cytoplasmic male sterility [PDF]
Daniel B. Sloan+4 more
openalex +1 more source
Benchmarks defining high‐quality sperm in the common marmoset (Callithrix jacchus)
Abstract Background Common marmosets (Callithrix jacchus) are increasingly recognized as valuable nonhuman primates (NHPs) for biomedical research due to their small size and short reproductive cycle and lifespan relative to other NHP species. Maximizing the utility of captive research marmosets, including genetically manipulated animals, will require ...
Niloofar Sadeghi+4 more
wiley +1 more source
Dexamethasone is a regulator of clock genes in testicular peritubular cells
Abstract Background We recently found that peritubular cells of the human testis are a dominant site of expression of the glucocorticoid receptor (GR; encoded by NR3C1). Activation of GR by dexamethasone (Dex) strongly influences the phenotype of cultured human testicular peritubular cells (HTPCs), causing massive changes of their proteome and ...
Harald Welter+11 more
wiley +1 more source
Temperature and Photoperiod Effects on Sterility in a Cytoplasmic Male‐Sterile Soybean
Bruce A. Smith+2 more
openalex +2 more sources