Results 131 to 140 of about 136,619 (315)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Hydroxymethylated cytosine in development and disease [PDF]

, 2013
Gerd P. Pfeifer
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Single Site Discrimination of Cytosine, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Target DNA Using Anthracene-Tagged Fluorescent Probes

, 2015
Jean‐Louis H. A. Duprey, Gemma A. Bullen, Zheng-yun Zhao, Dario M. Bassani, Anna F. A. Peacock, John Wilkie, James H. R. Tucker   +6 more
openalex   +2 more sources

Mutagenicity and Repair of Acrolein Adduct to Cytosine. [PDF]

Int J Mol Sci
Dylewska M, Kasperowicz S, Sokołowska B, Maciejewska AM.   +3 more
europepmc   +1 more source

Determination of cytosine, 3-methylcytosine, and 5-methylcytosine in nucleic acids by high performance liquid chromatography.

, 1977
Hidetaka Yuki, Hideki Kawasaki, Toshiko Kobayashi, Akira Yamaji   +3 more
openalex   +2 more sources

SPECTRAL ANALYSIS OF GUANINE AND CYTOSINE FLUCTUATIONS OF MOUSE GENOMIC DNA [PDF]

, 2004
WENTIAN LI, DIRK HOLSTE
openalex   +1 more source

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation [PDF]

, 2020
Jusik Kim, Keeeun Kim, Jung‐Soon Mo, Youngsoo Lee   +3 more
openalex   +1 more source

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

International Journal of Cancer, EarlyView.
What's New? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman, Nahal Masrour, Naina Patel, Anna M. Piskorz, Robert Brown, James D. Brenton, Iain A. McNeish, James M. Flanagan   +7 more
wiley   +1 more source

5mC and 5hmC methylation sequencing: the power of 6-base sequencing in a multiomic era. [PDF]

Epigenomics
Crawford R, Charlesworth T, Riffle S, Yardley K, Osborne R.   +4 more
europepmc   +1 more source