Results 181 to 190 of about 279,378 (380)

Ratiometric Detection of pH‐Induced i‐Motif Folding Based on a Dual Emissive Cytosine Analog

open access: yesChemBioChem, EarlyView.
A dual‐emissive cytosine analog enables ratiometric fluorescence detection of i‐motif DNA folding. This study reveals a sensitive method to monitor pH‐dependent i‐motif conformational changes, providing a valuable tool for investigating DNA secondary structures in vitro.
Nicolas P. F. Barthes   +3 more
wiley   +1 more source

Gold‐Mediated Base Pairs in Nucleic Acids: Selective Coordination to Natural and Thiocarbonyl‐Modified Cytosines Dependent upon the Oxidation State of Gold

open access: yesChemBioChem, EarlyView.
Selective coordination of gold ions to mismatched cytosines in nucleic acid duplexes is achieved via oxidation‐state‐dependent interactions. While Au(I) binds to natural cytosine–cytosine pairs, cytosine thiolation promotes square‐planar coordination with Au(III), offering a structure‐guided approach to redox‐tunable nucleic acid architectures.
Kai Kosugi   +7 more
wiley   +1 more source

Synthesis and Incorporation of a pH‐Responsive Nucleoside Into DNA Sequences

open access: yesChemBioChem, EarlyView.
A pH‐responsive nucleoside is developed that enables a reversible switch in DNA between paired and unpaired states near physiological pH. This design may provide the framework for sequence‐independent, pH programable DNA motifs, thus paving the way for dynamic DNA nanotechnology applications.
Eric Ogel, Sidney Becker
wiley   +1 more source

DNA‐Cytosine methylation in E. coli MRE 600 cells [PDF]

open access: bronze, 1976
Irina Bogdarina   +2 more
openalex   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

open access: yesChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang   +7 more
wiley   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore   +7 more
wiley   +1 more source

A pilot study on DNA methylation changes for non‐invasive molecular diagnostics in heart failure

open access: yesESC Heart Failure, EarlyView.
A liquid biopsy approach integrating the high‐resolution RRBS DNA methylation platform and network‐oriented strategy identified the hypomethylation of CPTA1, CKAP4, SPTB, SYT6, EIF2S2, and RAB11FIP1 genes as useful biomarkers in distinguishing between ischaemic and non‐ischaemic HF aetiologies.
Giuditta Benincasa   +7 more
wiley   +1 more source

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