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The SPR sensor detecting cytosine-cytosine mismatches

The SPR sensor detecting cytosine-cytosine mismatches
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Rastair: an integrated variant and methylation caller

Etzioni Z, Zhao L, Hertleif P, Schuster-Boeckler B.   +3 more
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Theoretical Study of Cytosine−Al, Cytosine−Cu and Cytosine−Ag (Neutral, Anionic and Cationic)

Journal of Physical Chemistry A, 2008
The binding of cytosine to Al, Cu and Ag has been analyzed using the hybrid B3LYP density functional theory method. The three metals all have open shell electronic configuration, with only one unpaired valence electron. Thus it is possible to study the influence of electronic configuration on the stability of these systems.
Ana Martinez
exaly   +3 more sources

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

Cell, 1983
In recent years 5methylcytosine residues in DNA have been implicated to have an important role in the control of eucaryotic gene expression (see Razin and Riggs, Science 210,604-610,198O). Consequently, there has been much interest in cytosine analogs such as 5azacytosine (5.azaC) and 5-fluorocytosine (5.fluoro-C), which, when incorporated into DNA ...
D V, Santi, C E, Garrett, P J, Barr
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Cytosine-cytosine+ base pairing stabilizes DNA quadruplexes and cytosine methylation greatly enhances the effect

Biochemistry, 1993
Previous spectroscopic studies demonstrated that the oligodeoxynucleotide d(CGC G3 GCG) undergoes a reversible cation-dependent transition between Watson-Crick (WC) hairpin and parallel-stranded "G-DNA" quadruplex structures [Hardin, C.C., Watson, T., Corregan, M., & Bailey, C. (1992) Biochemistry 31, 833-841].
C C, Hardin, M, Corregan, B A, Brown, L N, Frederick   +3 more
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Tautomeric exchange in cytosine

Biochemical and Biophysical Research Communications, 1971
Abstract It has long been noted that the H 5 proton of cytosine and its related derivatives exhibits unusually broad resonances in the pmr spectrum under certain conditions of temperature and solution pD. We have examined this phenomenon as a function of temperature, solution pD as well as the external magnetic field, and have shown that the line ...
G C, Lee, J H, Prestegard, S I, Chan
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Restricted rotation in crystalline cytosine and cytosine monohydrate

Transactions of the Faraday Society, 1970
The n.m.r. parameters T1 and T1ρ, the spin-lattice relaxation times in the laboratory- and rotating-frames, respectively, have been utilized to study the molecular motions that occur in polycrystalline samples of cytosine and cytosine hydrate in the range 130–293 K. The deuterated analogues have also been studied.
I. Adams, G. Parry Jones, J. M. Thomas
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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Annual Review of Biochemistry, 2005
▪ Abstract  Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is ...
Mary Grace, Goll, Timothy H, Bestor
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Solvolyses of Cytosine and Cytidine

Journal of Pharmaceutical Sciences, 1972
It has been confirmed by UV spectrophotometry and TLC that cytosine and cytidine deaminate to uracil and uridine, respectively, at all pH values. These products slowly degrade further in strongly alkaline solutions. Cytidine also undergoes a parallel degradation in strongly alkaline solutions to a nonchromophoric compound, which can be assigned to a ...
E R, Garrett, J, Tsau
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The SPR Sensor Detecting Cytosine−Cytosine Mismatches

Journal of the American Chemical Society, 2003
We have synthesized the first surface plasmon resonance (SPR) sensor that detects cytosine-cytosine (C[bond]C) mismatches in duplex DNA by immobilizing aminonaphthyridine dimer on the gold surface. The ligand consisting of two 2-aminonaphthyridine chromophores and an alkyl linker connecting them strongly stabilized the C[bond]C mismatches regardless of
Kobori, A, Horie, S, Suda, H, Saito, I, Nakatani, K   +4 more
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