Results 211 to 220 of about 133,095 (262)
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Protonation of cytosine in DNA
Biopolymers, 1966AbstractSpectrophotometric acid titrations of DNA samples of different GC content were performed at different wavelengths. From the acid titration profile and absorbance changes of deoxycytidine‐5′‐monophosphate and DNA the extent of protonated cytosine within the DNA double‐stranded molecule was estimated (pK 3.65 at 25°C. in 0.02M KCl).
C, Zimmer, H, Venner
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The Full Cytosine‐Cytosine Base Paring: Self‐Assembly and Crystal Structure
Chemistry – A European Journal, 2023AbstractThe synthesis of self‐assembly systems that can mimic partial biological behaviours require ingenious and delicate design. For decades, scientists are committed to exploring new base pairing patterns using hydrogen bonds directed self‐assembly of nucleotides.
Zhongkui Li +6 more
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Enzymology of cytosine arabinoside
Medical and Pediatric Oncology, 1982The enzymes responsible for the metabolism of Ara-C and its metabolites in human cells are described. The relevance of the properties of those enzymes to the action of Ara-C is discussed.
Y C, Cheng, R L, Capizzi
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How to Distinguish Methyl-Cytosine from Cytosine with High Fidelity
Journal of Molecular Biology, 2012Methylation of cytosines in the DNA is central to the epigenetic code. The patterns along the DNA formed by these chemical marks instruct the cell which proteins to express and their faithful maintenance after replication are vital to the organism's life.
Caterina, Bianchi, Ronen, Zangi
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The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites
Nature Structural Biology, 2001Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites.
Lisgarten, J.N. +4 more
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Determination of 5‐methyl‐cytosine and cytosine in tumor DNA of cancer patients
ELECTROPHORESIS, 2005AbstractThe determination of the relative methylation in DNA tumor samples, in order to evaluate the activity of some anti‐cancer drugs, has become a very important issue in the clinical field. Capillary electrophoresis (CE) applications in this area have been done previously but no good separation for model samples or tumor samples has been reported ...
Karina, Sandoval Guerrero +3 more
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Synthesis and structure of cytosine dichloride cuprate: direct bonding of copper to cytosine
Acta Crystallographica Section C Crystal Structure Communications, 1990Dichlorobis(cytosine)copper(II), [CuCl2-(C4H5N3O)2], Mr = 356.65, monoclinic, P2(1)/n, a = 8.399 (2), b = 13.773 (2), c = 10.775 (2) A, beta = 90.8 (2) degrees, V = 1246.3 (9) A3, Z = 4, Dx = 1.901 Mg m-3, lambda (Mo K alpha) = 0.7107 A, mu = 2.195 mm-1, F(000) = 716, T = 298 K, R = 0.032, wR = 0.037 for 2313 reflections greater than 2 sigma(F).
D, Tran Qui, E, Palacios
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Cytosine Methylation and DNA Repair
2006Cytosine methylation is a common form of post-replicative DNA modification seen in both bacteria and eukaryotes. Modified cytosines have long been known to act as hotspots for mutations due to the high rate of spontaneous deamination of this base to thymine, resulting in a G/T mismatch.
C P, Walsh, G L, Xu
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VARICELLA AND CYTOSINE ARABINOSIDE
The Lancet, 1970B R, Seligman, F, Rosner
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The SPR sensor detecting cytosine[bond]cytosine mismatches.
Journal of the American Chemical Society, 2004We have synthesized the first surface plasmon resonance (SPR) sensor that detects cytosine-cytosine (C[bond]C) mismatches in duplex DNA by immobilizing aminonaphthyridine dimer on the gold surface. The ligand consisting of two 2-aminonaphthyridine chromophores and an alkyl linker connecting them strongly stabilized the C[bond]C mismatches regardless of
Akio, Kobori +4 more
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