Results 301 to 310 of about 279,378 (380)

Methylome Profiling of a Deuterostome Invertebrate Using Oxford Nanopore Technology (ONT)

Molecular Ecology Resources, EarlyView.
ABSTRACT DNA methylation is crucial for genome regulation and provides key insights into the interaction between genetics and environmental factors, offering valuable perspectives for ecological research. However, knowledge of DNA methylation patterns in nonmodel invertebrates remains limited.
Sarah Lok Ting Kwong, Alyssa Maree Budd, Julia Yun‐Hsuan Hung, Cecilia Villacorta‐Rath, Sven Uthicke   +4 more
wiley   +1 more source

Protocol for single-base quantification of RNA m5C by pyrosequencing. [PDF]

STAR Protoc
Cayir A, Böttcher Y.
europepmc   +1 more source

Ultraperformance Liquid Chromatography Tandem Mass Spectrometry Assay of DNA Cytosine Methylation Excretion from Biological Systems. [PDF]

ACS Omega
Qu J, Kumar A, Liu YM, Odubanjo OV, Noubissi FK, Hu Y, Hu H.   +6 more
europepmc   +1 more source

Brain DNA Methylation Atlas of AppNL‐G‐F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline‐Induced Resilience

Aging Cell, EarlyView.
Brain DNA methylation drives abnormal gene expression in AppNL‐G‐F mice. Perinatal choline supplementation may promote resilience to synaptic dysfunction through modulation of DNA methylation. ABSTRACT Alzheimer's disease (AD) is the most common type of dementia.
Andre Krunic, Thomas A. Bellio, Benjamin Z. Cohen, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +7 more
wiley   +1 more source

Conformation-Dependent Lesion Bypass and Mutagenicity of Bulky 2-Acetylaminofluorene-Guanine DNA Adduct in Epigenetically Relevant Sequence Contexts. [PDF]

Chem Res Toxicol
Chen YT, Qi R, Cai A, Cho BP, Li D.
europepmc   +1 more source

Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells

Allergy, EarlyView.
This study analyzes molecular drivers of OIT responsiveness. Multi‐omics profiling of peanut‐stimulated PBMCs in a controlled peanut‐OIT trial identifies immune, transcriptomic, and epigenetic changes distinguishing complete responders from incomplete responders. Key findings highlight gastrointestinal immune mechanisms, including extracellular exosome
Aleix Arnau‐Soler, Sarah E. Ashley, Ahla Ghauri, Alexander C. S. N. Jeanrenaud, Ingo Marenholz, Katharina Blumchen, Penelope Cibin, Alisa Iakupova, Norbert Hubner, Kirsten Beyer, Young‐Ae Lee   +10 more
wiley   +1 more source

Genome‐Wide Blood DNA Methylation Profiling in Birch Pollen Allergic Patients Undergoing Allergen‐Specific Immunotherapy

Allergy, EarlyView.
Whole genome‐wide DNA methylation analysis of whole blood of patients undergoing 6 months of birch pollen subcutaneous allergen immunotherapy revealed epigenetic changes linked to allergen immunotherapy. Birch pollen AIT decreases methylation in HLA genes and induces methylation in genes associated with Th2 and TGF‐β pathways, increases CD8+ T cell ...
Angelika Lahnsteiner, Victoria Ellmer, Mengzhen Hao, Line Kring Tannert, Serge A. Versteeg, Carsten Bindslev‐Jensen, Ronald van Ree, Angela Risch, Lorenz Aglas   +8 more
wiley   +1 more source

Integration of omics data in the diagnosis and therapy of glioblastoma

Brain Pathology, EarlyView.
Integration of omics data in the diagnosis and therapy of glioblastoma. Abstract Since the 2016 update of the WHO Classification of Tumors of the Central Nervous System, omics data have been officially integrated into the diagnostic process for glioblastoma, the most prevalent and aggressive primary malignant brain tumor in adults.
Constantin Möller, Melanie Schoof, Keith L. Ligon, Ulrich Schüller   +3 more
wiley   +1 more source

Intramolecular Versus Intermolecular Bonding in Drug Gemcitabine and Nucleobases: A Computational Study. [PDF]

Molecules
Venkataramanan NS, Suvitha A, Sahara R.
europepmc   +1 more source

Identification of a distinct epigenetic subgroup with inferior PFS in intracranial mesenchymal tumors with FET::CREB fusion

Brain Pathology, EarlyView.
Six new cases of intracranial mesenchymal tumors with FET::CREB fusion, alongside 20 previously reported cases underwent DNA methylation profiling uncovered a novel epigenetic subgroup distinguished by inferior PFS and unique clinicopathological, molecular, and epigenetic hallmarks.
Yong Lin, Yun Ning, Yang Lan, Yu‐Juan Cao, Rui‐Jiao Zhao, Hai‐Nan Li, Song Duan, Wei‐Wei Fu, Hai‐Bo Wu, Feng Wu, Xiu‐Wu Bian, Tao Luo, Xiao‐Hong Yao   +12 more
wiley   +1 more source