Results 71 to 80 of about 279,378 (380)

{BiQ} Analyzer {HiMod}: An Interactive Software Tool for High-throughput Locus-specific Analysis of 5-Methylcytosine and its Oxidized Derivatives [PDF]

, 2014
Recent data suggest important biological roles for oxidative modifications of methylated cytosines, specifically hydroxymethylation, formylation and carboxylation. Several assays are now available for profiling these DNA modifications genome-wide as well
Becker, D., Bock, C., Ebert, P., Lengauer, T., Lutsik, P., Walter, J.   +5 more
core   +2 more sources

The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites

Nature Structural Biology, 2001
Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites.
Lisgarten, J.N., Coll, M., Portugal, J., Wright, Colin W., Aymami, J.   +4 more
openaire   +5 more sources

N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori

Nucleic Acids Research, 2018
Many bacterial genomes exclusively display an N4-methyl cytosine base (m4C), whose physiological significance is not yet clear. Helicobacter pylori is a carcinogenic bacterium and the leading cause of gastric cancer in humans.
Sumith Kumar, B. C. Karmakar, D. Nagarajan, A. Mukhopadhyay, R. Morgan, D. Rao   +5 more
semanticscholar   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Discovery of Bacterial Deaminases That Convert 5-Fluoroisocytosine Into 5-Fluorouracil

Frontiers in Microbiology, 2018
Cytosine is one of the four letters of a standard genetic code, found both in DNA and in RNA. This heterocyclic base can be converted into uracil upon the action of the well-known cytosine deaminase.
Agota Aučynaitė, Rasa Rutkienė, Daiva Tauraitė, Rolandas Meškys, Jaunius Urbonavičius, Jaunius Urbonavičius   +5 more
doaj   +1 more source

Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability

Nature Communications, 2016
Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC).
Thuy T. M. Ngo, J. Yoo, Qing Dai, Qiucen Zhang, Chuan He, A. Aksimentiev, T. Ha   +6 more
semanticscholar   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

Nature Communications, 2018
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts,
Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel Groot, V. Labrie, Peixin Jia, E. Oh, Richie Jeremian, M. Susic, Tenjin C. Shrestha, M. Ralph, J. Gordevičius, Karolis Koncevicius, A. Petronis   +15 more
semanticscholar   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

5-bromo- and 5-iodo-N-1-sulfonylated cytosine derivatives. Exclusive formation of keto-imino tautomers [PDF]

, 1999
N-1-Sulfonylated cytosine 5 and 5-halogeno-N-1-sulfonylated cytosine derivatives 1 and 2 were synthesized by condensation of silylated cytosine or 5-halogenocytosine bases with tosylchloride in acetonitrile, or by the reaction of cytosine or 5 ...
Krizmanić, Irena, Vikić-Topić, Dražen, Žinić, Biserka, Žinić, Mladen   +3 more
core   +1 more source