Results 51 to 60 of about 160,622 (298)

Ureido cytosine and cytosine-containing acrylic copolymers

Polymer Chemistry, 2016
Ureido-cytosine pendant groups contributed to random acrylic copolymers with enhanced thermomechanical performance, well-defined morphologies, and reduced water uptake.
Keren Zhang, Mingtao Chen, Kevin J. Drummey, Samantha J. Talley, Lindsey J. Anderson, Robert B. Moore, Timothy E. Long   +6 more
openaire   +2 more sources

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Cytosine methylation levels at CG, CHG, and CHH and total cytosine sites in WT and msa1-1.

, 2016
Cytosine methylation levels at CG, CHG, and CHH and total cytosine sites in WT and msa1-1.
Brian Dilkes (376800), Sanja Roje (2360476), Rüdiger Hell (157848), John Danku (88325), Anna Koprivova (157792), Dai-Yin Chao (137093), Stanislav Kopriva (62918), Francisco J. Sandoval (2360479), David E Salt (32009), Xin-Yuan Huang (2203642), Steffen Müller (152855), Markus Wirtz (157805), Hermann Bauwe (143130)   +12 more
core   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

The methylation landscape of giga-genome and the epigenetic timer of age in Chinese pine

Nature Communications, 2023
DNA methylation level declines during aging of mammals. Here, the authors report single-base resolution landscape of cytosine DNA methylation at different ages of Chinese pine and show that the global cytosine DNA methylation gradually increases as age ...
Jiang Li, Fangxu Han, Tongqi Yuan, Wei Li, Yue Li, Harry X. Wu, Hairong Wei, Shihui Niu   +7 more
doaj   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

SmPNP2 binds cytosine.

, 2018
A. Composite omit electron density map contoured at 1 σ for cytosine in the SmPNP2 active site. B. Cytosine H-bond interactions network in the SmPNP2 active site.
Yamini Reddivari (5728772), Louise Bird (136506), Muhammad Faheem (1767637), Larissa Romanello (5728763), Vitor Hugo Balasco Serrão (5728769), Ana Eliza Zeraik (5363126), Júlio César Borges (779971), José Brandão-Neto (3389366), Ricardo DeMarco (80218), Humberto D’Muniz Pereira (137347), Ray Owens (136510), Fernanda Aparecida Heleno Batista (5728766), Joanne Nettleship (29762), Juliana Roberta Torini (3389372)   +13 more
core   +1 more source

Detection of Cytosine methylation in ancient DNA from five native american populations using bisulfite sequencing.

PLoS ONE, 2015
While cytosine methylation has been widely studied in extant populations, relatively few studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic marks in ancient DNA have inferred patterns of methylation in highly degraded ...
Rick W A Smith, Cara Monroe, Deborah A Bolnick   +2 more
doaj   +1 more source

Genetic variations in the human cannabinoid receptor gene are associated with happiness.

PLoS ONE, 2014
Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level).
Masahiro Matsunaga, Tokiko Isowa, Kaori Yamakawa, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada, Hideki Ohira   +6 more
doaj   +1 more source

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria [PDF]

Proceedings of the National Academy of Sciences, 2011
Mitochondrial DNA (mtDNA) has been reported to contain 5-methylcytosine (5mC) at CpG dinucleotides, as in the nuclear genome, but neither the mechanism generating mtDNA methylation nor its functional significance is known. We now report the presence of 5-hydroxymethylcytosine (5hmC) as well as 5mC in mammalian mtDNA, suggesting that previous studies ...
Lisa S, Shock, Prashant V, Thakkar, Erica J, Peterson, Richard G, Moran, Shirley M, Taylor   +4 more
openaire   +2 more sources