Results 31 to 40 of about 160,622 (298)

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Molecular Cancer, 2020
Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated.
Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory, Pierre-François Cartron   +15 more
doaj   +1 more source

Enzymatic approaches for profiling cytosine methylation and hydroxymethylation

Molecular Metabolism, 2022
Background: In mammals, modifications to cytosine bases, particularly in cytosine-guanine (CpG) dinucleotide contexts, play a major role in shaping the epigenome.
Tong Wang, Christian E. Loo, Rahul M. Kohli   +2 more
doaj   +1 more source

Cytosine-Based TET Enzyme Inhibitors

, 2019
DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered ...
Beth G. Malachowsky (6298331), Martin Kruse (6298334), Kelly L. Wassarman (6298316), Joseph A. Alp (6298322), Emma I. Jarczyk (6298325), Gabriella N. L. Chua (6298313), Michael J. Bennett (172679), Andrew J. Kennedy (2196862), Nathanael J. Kuzio (6298328), Haoyu Sun (6298319)   +9 more
core   +1 more source

Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species

mBio, 2023
Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and cytosine deaminase are known major players in flucytosine resistance by regulating uptake and ...
Dong-Hoon Yang, Ami Khanal Lamichhane, Kyung J. Kwon-Chung, Yun C. Chang   +3 more
doaj   +1 more source

Cytosine Binding in the Novel Organoplatinum(II) Complex [(COD)PtMe(cytosine)](SbF₆)^†

, 2016
The organoplatinum fragment [(COD)PtMe] (COD = 1,5-cyclooctadiene) binds to cytosine mainly via the N(3) atom in the water-stable organoplatinum complex [(COD)PtMe(cytosine)]+.
Harald Scherer (1647223), Nalinava Sen Gupta (2208706), Axel Klein (1938667), Thilo Schurr (2364154)   +3 more
core   +2 more sources

Effectiveness of the enzyme cytosine deaminase in the free living ciliary organism Tetrahymena pyriformis (Ehrenberg, 1830) [PDF]

مجلة التربية والعلم, 2008
Cytosine deaminase (EC.3.5.4.1) activity and properties was determined in the extract of the free living ciliata Tetrahymena pyriformis grown in proteose peptone medium. The optimum conditions for the enzyme activity was also determined and it was found
Zahraa Bashi, Muna Jankeer
doaj   +1 more source

Cytosine DNA Methylation.

, 2014
Cytosine DNA methylation is a epigenetic mechanisms that affects gene expression. It involves the addition of a methyl group to the cytosine DNA nucleotides.
Luciano Milanesi (28769), Giuliano Armano (28767), Andrea Manconi (566020), Emanuele Manca (566021), Alessandro Orro (28770)   +4 more
core   +1 more source

A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

eLife, 2021
Shotgun metagenomic sequencing is a powerful approach to study microbiomes in an unbiased manner and of increasing relevance for identifying novel enzymatic functions.
Weiwei Yang, Yu-Cheng Lin, William Johnson, Nan Dai, Romualdas Vaisvila, Peter Weigele, Yan-Jiun Lee, Ivan R Corrêa Jr, Ira Schildkraut, Laurence Ettwiller   +9 more
doaj   +1 more source

Global DNA cytosine methylation as an evolving trait: phylogenetic signal and correlated evolution with genome size in Angiosperms

Frontiers in Genetics, 2015
DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered ...
Conchita eAlonso, Ricardo ePérez, Pilar eBazaga, Carlos M Herrera   +3 more
doaj   +1 more source

Physicochemical and statistical characterization of gas-sensing behaviors of resonator sensors with carbonaceous films prepared by rf-sputtering of aromatic and hydrophilic biomolecules

Results in Chemistry, 2022
Quartz crystal resonators coated with gas-sorptive films were characterized by analyzing their structures and their organic gas-sorption behaviors, which were then studied using statistics and computational molecular simulations.
Iwao Sugimoto, Yoriko Suda, Kazuhiko Takahashi   +2 more
doaj   +1 more source