Results 11 to 20 of about 131,177 (265)

Protonated nucleobases are not fully ionized in their chloride salt crystals and form metastable base pairs further stabilized by the surrounding anions

IUCrJ, 2018
This paper presents experimental charge-density studies of cytosinium chloride, adeninium chloride hemihydrate and guaninium dichloride crystals based on ultra-high-resolution X-ray diffraction data and extensive theoretical calculations.
Prashant Kumar, Malgorzata Katarzyna Cabaj, Aleksandra Pazio, Paulina Maria Dominiak   +3 more
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Tricky Topology: Persistence of Folded Human Telomeric i-Motif DNA at Ambient Temperature and Neutral pH

Frontiers in Chemistry, 2020
i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology.
Mahmoud A. S. Abdelhamid, Mahmoud A. S. Abdelhamid, Zoë A. E. Waller, Zoë A. E. Waller   +3 more
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Radiological Evaluation of Huntington’s Disease: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Huntington’s Disease (HD) is a rare neurodegenerative condition inherited in an autosomal dominant pattern, where Gamma Amino Butyric Acid-ergic (GABAergic) neurons in the basal ganglia progressively deteriorate.
Soumyabrata Debnath, R Harshith
doaj   +1 more source

Simultaneous Determination of Four DNA bases at Graphene Oxide/Multi-Walled Carbon Nanotube Nanocomposite-Modified Electrode

Micromachines, 2020
In this study, we developed a modified glassy carbon electrode (GCE) with graphene oxide, multi-walled carbon nanotube hybrid nanocomposite in chitosan (GCE/GO-MWCNT-CHT) to achieve simultaneous detection of four nucleobases (i.e., guanine (G), adenine ...
Shuting Wang, Celia Ferrag, Meissam Noroozifar, Kagan Kerman   +3 more
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Synthesis and Structural Study of Some Pyrimidinium Hexafluoridosilicates

Acta Chimica Slovenica, 2015
The synthesis and spectroscopic characterization of some pyrimidinium hexafluoridosilicate salts with the formula (RH)2[SiF]6 (where R = 2-aminopyrimidine (1), cytosine (2) and 5-cyanocytosine (3)) is obtained in the reaction of SiO2 with hydrofluoric ...
Andrej Pevec
doaj   +1 more source

Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry

Molecules, 2019
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng, Yanyan Zhang, Wei Zheng, Qun Luo, Juanjuan Han, Jian’an Liu, Yao Zhao, Feifei Jia, Kui Wu, Fuyi Wang   +9 more
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CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity

BMC Genetics, 2020
Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel, Divyesh Patel, Subhamoy Datta, Umashankar Singh   +3 more
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Evaluating Relative Retention of Polar Stationary Phases in Hydrophilic Interaction Chromatography

Separations, 2019
A large number of polar stationary phases with diverse chemistry have been developed for various applications in hydrophilic interaction chromatography (HILIC).
Yong Guo, Nidhi Bhalodia, Bassel Fattal
doaj   +1 more source

In silico structural analysis of sequences containing 5-hydroxymethylcytosine reveals its potential as binding regulator for development, ageing and cancer-related transcription factors

Epigenetics, 2021
The presence of 5-hydroxymethyl cytosine in DNA has been previously associated with ageing. Using in silico analysis of normal liver samples we presently observed that in 5-hydroxymethyl cytosine sequences, DNA methylation is dependent on the co-presence
Andigoni Malousi, Alexandra-Zoi Andreou, Sofia Kouidou   +2 more
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Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Molecular Cancer, 2020
Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated.
Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory, Pierre-François Cartron   +15 more
doaj   +1 more source