Results 11 to 20 of about 160,622 (298)
A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. [PDF]
PLoS ONE, 2014 We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme's active ...
Scott T Kimber, Tom Brown, Keith R Fox
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Cytosine-to-uracil deamination by SssI DNA methyltransferase. [PDF]
PLoS ONE, 2013 The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Ildikó Stier, Antal Kiss
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ComputationMetal-mediated base pairs in DNA double helix molecules open up broad opportunities for biosensors based on DNA clusters with silver due to their low toxicity and applicability in drug design.
Elena B. Gusarova, Natalya A. Kovaleva
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Occurrence, Properties, Applications and Analytics of Cytosine and Its Derivatives
MoleculesCytosine and its derivatives are an important research topic in the fields of bioorganic chemistry, molecular biology and medicine due to their key role in the structure and function of nucleic acids.
Mariusz Kluska +3 more
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APOBEC3 activity and DNA polymerase-ε deficiency are associated with distinct IDH1 R132 hotspot mutations. [PDF]
Mol OncolIsocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Butler KE, Lone BA, Unal E, Banday AR.
europepmc +2 more sources
Quantum Chemical Study on Interstellar Synthesis of Cytosine by the Automated Reaction Path Search [PDF]
, 2022 Novel reaction pathways with the neutral radical-molecule reaction to form cytosine, a nucleobase of DNA and RNA, which can proceed in the interstellar environment, were discovered by automated reaction pathway calculations based on transition state ...
YU, KOMATSU, Taiki, Suzuki
core +2 more sources
, 2016 A workflow for screening and manufacturing co-crystals was used to produce 4:1 co-crystal of cytosine−oxalic acid dihydrate, 2:1 co-crystal of cytosine−malonic acid, and 2:1 co-crystal of cytosine−succinic acid with melting points of 270.2, 219.2, and ...
Tu Lee (1819789), Pu Yun Wang (2314825)
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A radioimmunoassay for cytosine arabinoside [PDF]
British Journal of Cancer, 1979 A radioimmunoassay (RIA) for cytosine arabinoside (AraC) has been developed using antiserum raised in a sheep to an AraC monophosphate-ovalbumin conjugate. The antibody shows only 0.008% cross-reactivity with uracil arabinoside (AraU) and low (0.023%) cross-reactivity with other commonly co-administered drugs such as cytotoxic and antibacterial agents,
E M, Piall, G W, Aherne, V M, Marks
openaire +2 more sources
Watson–Crick and Sugar-Edge Base Pairing of Cytosine in the Gas Phase: UV and Infrared Spectra of Cytosine·2-Pyridone [PDF]
, 2014 While keto-amino cytosine is the dominant species in aqueous solution, spectroscopic studies in molecular beams and in noble gas matrices show that other cytosine tautomers prevail in apolar environments. Each of these offers two or three H-bonding sites
Ottiger, Philipp +5 more
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Frontiers in Chemistry, 2020 i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology.
Mahmoud A. S. Abdelhamid +3 more
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