Results 91 to 100 of about 160,622 (298)

Accelerated Epigenetic Aging in Frontotemporal Dementia Highlights Smoking, Inflammation, and Metabolic Signals

Annals of Neurology, EarlyView.
Objective Epigenetic clocks are biomarkers of biological aging influenced by lifestyle and systemic factors. Accelerated epigenetic aging has been associated with neurodegeneration, but its relevance in frontotemporal dementia is unclear. We investigated biological aging in frontotemporal dementia using the GrimAge2 epigenetic clock, a DNA methylation ...
Daphne Nijland, Sven J. van der Lee, Eska Marye de Haan, Naren Ramesh, Sterre C.M. de Boer, Everard G.B. Vijverberg, Henne Holstege, Yolande A.L. Pijnenburg, Roel A. Ophoff, Lianne M. Reus   +9 more
wiley   +1 more source

Density Functional Theory Investigation on Muon Hyperfine Interaction in Methylated Guanine-Cytosine Double-Strand DNA

Journal of Mathematical and Fundamental Sciences
The aims of this study were to determine the most likely Mu trapping sites based on total energy consideration as well as identifying the associated muon hyperfine coupling constant of 1, 2, and 3 methylated guanine-cytosine base pair double-strand DNA.
Ammaina Jamaludin, Shukri Sulaiman, Wan Nuradhilah Zaharim, Ang Lee Sin   +3 more
doaj   +3 more sources

DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha) [PDF]

, 2013
Review on DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha), with data on DNA, on the protein encoded, and where the gene is ...
Kuo, YY, Li, LY, Tien, HF
core   +1 more source

Synthesis of magnetic cytosine-imprinted chitosan nanoparticles

, 2017
Molecularly imprinted polymer nanoparticles incorporating magnetic nanoparticles (MNPs) have been investigated for their selective adsorption properties.
Lee, Mei Hwa, Chen, Jian Zhou, Lin, Hung Yin, Shih, Neng Lang, AHLUWALIA, ARTI DEVI   +4 more
core   +1 more source

DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) [PDF]

, 2013
Review on DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta), with data on DNA, on the protein encoded, and where the gene is ...
Trimeche, M, Ben, Gacem R, Ben, Abdelkrim O, Ziadi, S   +3 more
core   +1 more source

Cytosine base editor-DNA binding domain fusions for editing window modulation in the RNP format

BMC Biotechnology
Summary Base editing technologies allow for the precise and efficient installation of defined nucleotide substitutions into a target genome without the introduction of double strand breaks or DNA templates.
Erin Brettmann, Fuqiang Chen, Stephen Beishir, Graeme Garvey   +3 more
doaj   +1 more source

NIR-laser-induced selective rotamerization of hydroxy conformers of cytosine

, 2010
The relative populations of two amino-hydroxy conformers of cytosine, differing in rotation of the OH group by 180°, were selectively and repeatedly manipulated with narrowband, near-infrared laser light.
Maciej J. Nowak, Lapinski, Leszek, Leszek Lapinski, Reva, Igor, Hanna Rostkowska, Nowak, Maciej J., Rostkowska, Hanna, Fausto, Rui, Rui Fausto, Igor Reva   +9 more
core   +1 more source

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

Nature Communications
The engineered TadA variants used in cytosine base editors (CBEs) present distinctive advantages, including a smaller size and fewer off-target effects compared to cytosine base editors that rely on natural deaminases.
Guoling Li, Xue Dong, Jiamin Luo, Tanglong Yuan, Tong Li, Guoli Zhao, Hainan Zhang, Jingxing Zhou, Zhenhai Zeng, Shuna Cui, Haoqiang Wang, Yin Wang, Yuyang Yu, Yuan Yuan, Erwei Zuo, Chunlong Xu, Jinhai Huang, Yingsi Zhou   +17 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

DNMT1 (DNA (cytosine-5-)-methyltransferase 1)) [PDF]

, 2009
Review on DNMT1 (DNA (cytosine-5-)-methyltransferase 1)), with data on DNA, on the protein encoded, and where the gene is ...
Kanai, Y, Arai, E
core   +1 more source