Results 81 to 90 of about 52,861 (267)
Spectral Analysis of Guanine and Cytosine Fluctuations of Mouse Genomic DNA [PDF]
Fluctuation and Noise Letters, 4(3):L453-L464 (2004), 2004 We study global fluctuations of the guanine and cytosine base content (GC%) in mouse genomic DNA using spectral analyses. Power spectra S(f) of GC% fluctuations in all nineteen autosomal and two sex chromosomes are observed to have the universal functional form S(f) \sim 1/f^alpha (alpha \approx 1) over several orders of magnitude in the frequency ...
arxiv +1 more source
DNA and Cell Biology, 2017 Plants have evolved several strategies, including regulation of genes through epigenetic modifications, to cope with environmental stresses. DNA methylation is dynamically regulated through the methylation and demethylation of cytosine in response to ...
Suresh Kumar +3 more
semanticscholar +1 more source
Structural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene
Advanced Science, EarlyView.This study first reports that the intron 1 of NOP56 oncogene forms an antiparallel chair‐type G4 structure composed of two G‐tetrads and one C∙G∙C∙G tetrad. NOP56 gene transcription can be inhibited by PDS that binds and stabilizes NOP56‐G4. Solution NMR structures of the free NOP56‐G4 and NOP56‐G4‐PDS complex provide valuable insights into G4 ...
Zhenzhen Yan +11 more
wiley +1 more source
Activity on non-methylated DNA limits the use of endonuclease MspJI for epigenetic analyses
All Results Journals: Biol, 2018 Cytosine methylation of DNA in mammals has been associated with both physiological and pathological changes in gene-expression. DNA treatment with methylation sensitive and/or dependent restriction enzymes, followed by PCR amplification is a widely used ...
María Belén Jerez +1 more
doaj
Nucleic Acids Research, 2015 The function of RNA is subtly modulated by post-transcriptional modifications. Here, we report an important crosstalk in the covalent modification of two classes of RNAs. We demonstrate that yeast Kre33 and human NAT10 are RNA cytosine acetyltransferases
Sunny Sharma +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.A laser‐induced forward transfer‐assisted microfiltration system is developed for single rare cell sorting from undiluted whole blood. The isolated cell has a high viability, enabling successful ex vivo cell culture and efficient single‐cell RNA sequencing.
Qingmei Xu +16 more
wiley +1 more source
ComputationMetal-mediated base pairs in DNA double helix molecules open up broad opportunities for biosensors based on DNA clusters with silver due to their low toxicity and applicability in drug design.
Elena B. Gusarova, Natalya A. Kovaleva
doaj +1 more source
DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing
Nature Communications, 2023 There is a need to improve and expand mitochondrial base editing tools. Here the authors identify a DddA homolog from Simiaoa sunii (Ddd_Ss) which can efficiently deaminate cytosine in dsDNA; they develop cytosine base editors and introduce mutations at ...
Li Mi +13 more
doaj +1 more source
TET proteins and the control of cytosine demethylation in cancer
Genome Medicine, 2015 The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine and 5-carboxycytosine has revealed new ...
L. Scourzic, Enguerran Mouly, O. Bernard
semanticscholar +1 more source
Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations
Advanced Science, EarlyView.Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou +6 more
wiley +1 more source