Results 81 to 90 of about 196,328 (291)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Desmin and dystrophin abnormalities in upper airway muscles of snorers and patients with sleep apnea

Respiratory Research, 2019
Background The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes.
Farhan Shah, Karl A. Franklin, Thorbjörn Holmlund, Eva Levring Jäghagen, Diana Berggren, Sture Forsgren, Per Stål   +6 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Distribution of cytoskeletal and adhesion proteins in adult zebrafish skeletal muscle [PDF]

, 2009
The organization of cytoskeletal and adhesion proteins in skeletal muscle is critical for its contractile function. Zebrafish has become a paramount model for studies of vertebrate biology, including muscle.
Mermelstein, C.S., Câmara-Pereira, E.S., Campos, L.M., Vannier-Santos, M.A., Costa, M.L.   +4 more
core   +2 more sources

Aluminum induces the in vitro aggregation of bovine brain cytoskeletal proteins

, 1990
The addition of aluminum to purified cytoskeletal proteins in vitro selectively induces the aggregation of highly phosphorylated proteins, such as the two larger neurofilament subunits (200 and 160 kDa) and the microtubule-associated proteins of the MAP ...
Díaz-Nido, Javier, Ávila, Jesús
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration [PDF]

, 2013
Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration.
Cengiz, P, Yuan Hui, Baba, Akemichi, Vishal Chanana, Chanana, V, Dong Kim (443919), Shi Yejie, Sun Dandan, Dandan Sun, Zhang, Zhe, Hui Yuan, Sun, Dandan, Toshio Matsuda, Yejie Shi, Akemichi Baba, An Sun, Matsuda Toshio, Peter Ferrazzano, Matsuda, Toshio, Pelin Cengiz, Akemichi Baba (253010), Baba, A, Shi, Y, Ferrazzano, Peter, Ferrazzano Peter, Hui Yuan (402180), Kim, Dong, Dong Kim, Sun, D, Vishal Chanana (448559), Shi, Yejie, Cengiz, Pelin, Toshio Matsuda (448560), Ferrazzano, P, Matsuda, T, Yuan, H, Peter Ferrazzano (448562), Dandan Sun (448563), Kim, D, Chanana, Vishal, Baba Akemichi, Pelin Cengiz (448561), Cengiz Pelin, Yuan, Hui, Yejie Shi (448558), Kim Dong, Chanana Vishal   +46 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A proteomic analysis of differentiating dopamine neurons derived from human embryonic stem cells

Animal Cells and Systems, 2019
Human embryonic stem cells (hESC) are being exploited for potential use in cell transplantation due to their capacity for self-renewal and pluripotency. Dopamine (DA) neurons derived from hESC represent a promising source of cell replacement therapy for ...
Joohyun Ryu, Byoung Chul Park, Do Hee Lee   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source