Results 101 to 110 of about 291,933 (344)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Consciousness operates beyond the timescale for discerning time intervals: implications for Q-mind theories and analysis of quantum decoherence in brain [PDF]

, 2003
This paper presents in details how the subjective time is constructed by the brain cortex via reading packets of information called "time labels", produced by the right basal ganglia that act as brain timekeeper.
Georgiev, Danko
core  

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Immunohistochemical changes in kidney glomerular and tubular proteins caused by rattlesnake (Crotalus vegrandis) venom

Revista do Instituto de Medicina Tropical de São Paulo, 2003
Renal damage is an important cause of death in patients who have survived the early effects of severe crotalid envenomation. Extracellular matrix of renal tissue is altered by Crotalus toxin activities.
María E. Girón, Irma Aguilar, Alexis Rodríguez-Acosta   +2 more
doaj  

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Biomedical Papers, 2017
Aims: The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins ...
Lenka Fialova, Ales Bartos, Jana Svarcova   +2 more
doaj   +1 more source

Cytoskeletal protein expression in planarians

Bolletino di zoologia, 1993
Abstract In freshwater planarians the existence of at least two major actin isoforms has been demonstrated. One isoform is expressed by differentiated muscle cells and is different from vertebrate α‐sarcomeric and α‐smooth actin. The other isoform is recognized by a specific anti warm‐blooded vertebrate α‐smooth muscle actin monoclonal antibody.
PASCOLINI, Rita, PANARA, Fausto, FAGOTTI, Anna, DI ROSA, Ines, SIMONCELLI, Francesca, Gabbiani G.   +5 more
openaire   +2 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells

Frontiers in Cellular Neuroscience
IntroductionNeural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders.
Nataliya Romanyuk, Kristyna Sintakova, Kristyna Sintakova, Ivan Arzhanov, Ivan Arzhanov, Martin Horak, Chirag Gandhi, Meena Jhanwar-Uniyal, Pavla Jendelova   +8 more
doaj   +1 more source

Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity [PDF]

Memorias do Instituto Oswaldo Cruz
BACKGROUND It was previously demonstrated that CMC-20, a nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, had higher in vitro activity against Giardia intestinalis WB strain than metronidazole and albendazole and similar to nitazoxanide ...
Félix Matadamas-Martínez, Benjamín Nogueda-Torres, Rafael Castillo, Alicia Hernández-Campos, María de la Luz Barrera-Valdes, Gloria León-Ávila, José Manuel Hernández, Lilián Yépez-Mulia   +7 more
doaj   +2 more sources

Integrin Activates Receptor-Like Protein Tyrosine Phosphatase α, Src, and Rho to Increase Prolactin Gene Expression through a Final Phosphatidylinositol 3-Kinase/Cytoskeletal Pathway that Is Additive with Insulin [PDF]

, 2005
Anthony I. Vulin, Kirsten K. Jacob, Frederick M. Stanley   +2 more
openalex   +1 more source