Results 101 to 110 of about 196,328 (291)

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Immunohistochemical changes in kidney glomerular and tubular proteins caused by rattlesnake (Crotalus vegrandis) venom

Revista do Instituto de Medicina Tropical de São Paulo, 2003
Renal damage is an important cause of death in patients who have survived the early effects of severe crotalid envenomation. Extracellular matrix of renal tissue is altered by Crotalus toxin activities.
María E. Girón, Irma Aguilar, Alexis Rodríguez-Acosta   +2 more
doaj  

Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity [PDF]

Memorias do Instituto Oswaldo Cruz
BACKGROUND It was previously demonstrated that CMC-20, a nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, had higher in vitro activity against Giardia intestinalis WB strain than metronidazole and albendazole and similar to nitazoxanide ...
Félix Matadamas-Martínez, Benjamín Nogueda-Torres, Rafael Castillo, Alicia Hernández-Campos, María de la Luz Barrera-Valdes, Gloria León-Ávila, José Manuel Hernández, Lilián Yépez-Mulia   +7 more
doaj   +2 more sources

Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes

, 1992
Axonal transport is known to be impaired in peripheral nerve of experimentally diabetic rats. As axonal transport is dependent on the integrity of the neuronal cytoskeleton, we have studied the way in which rat brain and nerve cytoskeletal proteins are ...
McLean, W. Graham, Casson, Ian F., Can Pekiner, Pekiner, Can, Cullum, Nicola A.; id_orcid, Nicola A. Cullum, W. Graham McLean, Ian F. Casson   +7 more
core   +1 more source

Concerted upregulation of CLP36 and smooth muscle actin protein expression in human endometrium during decidualization [PDF]

, 2005
The human endometrium prepares for implantation of the blastocyst by reorganization of its whole cellular network. Endometrial stroma cells change their phenotype starting around the 23rd day of the menstrual cycle.
Neumaier-Wagner, Peruka, Huppertz, Berthold, Goyal, Pankaj, Rath, Werner, Miehe, Ulrich, Kadyrov, Mamed, Alfer, Joachim   +6 more
core   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells

Frontiers in Cellular Neuroscience
IntroductionNeural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders.
Nataliya Romanyuk, Kristyna Sintakova, Kristyna Sintakova, Ivan Arzhanov, Ivan Arzhanov, Martin Horak, Chirag Gandhi, Meena Jhanwar-Uniyal, Pavla Jendelova   +8 more
doaj   +1 more source

Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly

Journal of Cardiovascular Development and Disease, 2016
Cardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional ...
Ouarda Taghli-Lamallem, Emilie Plantié, Krzysztof Jagla   +2 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

The slow axonal transport of cytoskeletal proteins

Current Opinion in Cell Biology, 1998
Once presumed to be relatively uniform, the axonal cytoskeleton can vary markedly in size and composition along its length. New studies emphasize the interactiveness of neurofilaments and identify a family of cytoskeletal proteins that may cross-link the various cytoskeletal polymers of the axon, and anchor this network to the membrane skeleton.
openaire   +2 more sources