Results 111 to 120 of about 555,685 (380)

Patterns in Space: Coordinating Adhesion and Actomyosin Contractility at E-cadherin Junctions

, 2013
Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their biological actions through active cooperation with the contractile actin ...
Wu, Selwin K., Yap, Alpha S.
core   +1 more source

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]

, 2009
: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
A Cuconati, A Gross, A Muller, A Zychlinsky, AG Letai, B Antonsson, C Dehio, CR Hauck, DR Green, E Oda, EM Kupsch, FJ Bauer, G Kroemer, Guido Kroemer, H Kim, H Puthalakath, H Puthalakath, H. Steven Seifert, HL Howie, IM Mosleh, J Zha, JB Bliska, K Lei, K Nakano, K Rajalingam, K Rajalingam, K Wang, Kathleen Gottschalk, Krishnaraj Rajalingam, L Chen, M Naumann, M Naumann, M Naumann, MA Apicella, MC Wei, N Machuy, N Tajeddine, Nikolaus Machuy, O Billker, O Kepp, Oliver Kepp, P Massari, P Muenzner, P Muenzner, PF Cartron, S Cory, S Makino, SE McCaw, SM Frisch, SN Willis, T Kuwana, T Rudel, T Schmelzle, Thomas Rudel, Volker Brinkmann, Yuri Churin, Z Xia   +56 more
core   +4 more sources

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

The Cytoskeleton in Papillomavirus Infection [PDF]

Viruses, 2011
Cytoskeleton defines the shape and structural organization of the cell. Its elements participate in cell motility, intracellular transport and chromosome movement during mitosis. Papillomaviruses (PV) are strictly epitheliotropic and induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy. Like many other viruses, PV use
Malgorzata Bienkowska-Haba, Martin Sapp
openaire   +3 more sources

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Nature Cell Biology, 2023
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen L. Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Zhuang Li, M. Poyurovsky, M. James You, Traver Hart, D. Billadeau, Junjie Chen, B. Gan   +18 more
semanticscholar   +1 more source

The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration

International Journal of Molecular Sciences, 2019
The retinal pigment epithelium (RPE) is a unique epithelium, with major roles which are essential in the visual cycle and homeostasis of the outer retina.
I. Ţărău, Andreas Berlin, C. Curcio, T. Ach   +3 more
semanticscholar   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Cytoskeleton as an Emerging Target of Anthrax Toxins

Toxins, 2012
Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET).
Jean-Nicolas Tournier, Yannick Trescos
doaj   +1 more source

Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice

Hepatology, 2018
High invasiveness is a hallmark of human hepatocellular carcinoma (HCC). Large tumors predict invasion and metastasis. Epithelial‐mesenchymal transition (EMT) is crucial for cancer invasion and metastasis.
Jei-Ming Peng, R. Bera, C. Chiou, Ming-Chin Yu, Tse-Chin Chen, Chia‐Wei Chen, T. Wang, Wan-Ling Chiang, S. Chai, Yongkun Wei, Huamin Wang, M. Hung, S. Hsieh   +12 more
semanticscholar   +1 more source