Results 101 to 110 of about 453,068 (302)
The cytosol activity of thymidine phosphorylase in endometrial cancer
Journal of Experimental & Clinical Cancer Research, 2008 Background Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor samples from patients with ...
Bieńkiewicz Andrzej +3 more
doaj +1 more source
Targeting of the prion protein to the cytosol: mechanisms and consequences
, 2010 Prion diseases are characterized by the conformational transition of the cellular prion protein (PrPC) into an aberrant protein conformer, designated scrapie-prion protein (PrPSc).
Miesbauer, M. +3 more
core
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]
, 2012 All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude +13 more
core +3 more sources
Advanced Science, EarlyView.TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao +4 more
wiley +1 more source
Estrogen Binding Protein Activity in Morris Hepatoma 7777 Compared With Normal Rat Liver [PDF]
, 1984 Estrogen binding protein activities were determined in the cytosol from adult male Buffalo rat liver and Morris hepatoma 7777. Estrogen receptors were prepared using the protamine sulfate precipitation technique of Chamness.
Dileo, A +7 more
core +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
PKCα and CPI-17 expression and spatial-temporal distribution with activation in pig stomach antrum and fundus [PDF]
, 2010 Smooth muscle contraction is a complicated process coordinated by contractile, regulatory and cytoskeletal proteins. The force generation depends on the phosphorylation of Myosin Regulatory Light Chain (MLC20). Myosin Light Chain Kinase (MLCK) and Myosin
Zhang, Yu
core +1 more source
Cell-Penetrating Peptides, Electroporation, and Drug Delivery
, 2010 Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis.
Cahill, Kevin
core +1 more source
Fluorescence Correlation Spectroscopy Reveals Efficient Cytosolic Delivery of Protein Cargo by Cell-Permeant Miniature Proteins. [PDF]
, 2018 New methods for delivering proteins into the cytosol of mammalian cells are being reported at a rapid pace. Differentiating between these methods in a quantitative manner is difficult, however, as most assays for evaluating cytosolic protein delivery are
Knox, Susan L +4 more
core +2 more sources
, 2006 The crowded cytosol is a special environment where weak interactions can be important. Here many macromolecules are close to the limits of their solubility, a condition conducive to weak, but specific, entropy-driven molecular interactions. In addition to being under evolutionary constraint to preserve the functions of their own products, genes ...
openaire +1 more source