Results 121 to 130 of about 453,295 (313)

Interactions between Magnetic Nanowires and Living Cells : Uptake, Toxicity and Degradation

, 2011
We report on the uptake, toxicity and degradation of magnetic nanowires by NIH/3T3 mouse fibroblasts. Magnetic nanowires of diameters 200 nm and lengths comprised between 1 {\mu}m and 40 {\mu}m are fabricated by controlled assembly of iron oxide ({\gamma}
Armelle Baeza-Squiban, Auffan M., Berret J.-F., Brunner T. J., Cappallo N., Champion J. A., Chanteau B., Conner S. D., Denizot F., Dietrich Averbeck, Donaldson K., Doshi N., Dumortier H., Florence Niedergang, Fresnais J., Fresnais J., Fresnais J., Fung A. O., Goubault C., Gratton S. E. A., Hallstrom W., Hillaireau H., Hultgren A., Hurst S. J., Hussain S., Hélène Conjeaud, Jacquin M., Jean-François Berret, Johansson F., Kagan V. E., Kim J., Kuimova M. K., Leung K. C. F., Lewinski N., Lutz J.-F. o., Malak Safi, Marie-Alice Guedeau-Boudeville, Massart R., Minhao Yan, Nan A. J., Nicole Boggetto, Niedergang F., Petri-Fink A., Pisanic T. R., Rad A. M., Safi M., Sehgal A., Singh H., Singh N., Song M. M., Tanase M., Virginie Garnier-Thibaud   +51 more
core   +2 more sources

Metabolic Studies in a Patient with Hepatic Cytosol Tyrosine Aminotransferase Deficiency [PDF]

, 1971
Nancy G. Kennaway, Neil R.M. Buist
openalex   +1 more source

Magnetic Resonance Imaging‐Based Quantification of Endosomal Escape Using Iron Oxide Nanoparticle‐Loaded Lipid Nanoparticles

Advanced Healthcare Materials, EarlyView.
The therapeutic efficacy of lipid nanoparticle(LNP)‐based drugs depends on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying the endosomal escape efficiency index using magnetic resonance imaging is introduced.
Somin Lee, Jeongbin Park, Han Na Jung, Shengjun Li, Zhijun Lin, Hyung‐Jun Im   +5 more
wiley   +1 more source

Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery

Molecular Therapy: Oncology
Although a considerable number of disease-related biomolecular interactions occur in the cytosol, therapeutic and diagnostic application of target-specific binding proteins is largely confined to surface-exposed or extracellular targets.
Carolin Sophie Dombrowsky, Felix Klaus Geyer, Diana Zakharchuk, Harald Kolmar   +3 more
doaj   +1 more source

Dielectric behaviour of graded spherical cells with an intrinsic dispersion

, 2004
The dielectric properties of single-shell spherical cells with an intrinsic dielectric dispersion has been investigated. By means of the dielectric dispersion spectral representation (DDSR) for the Clausius-Mossotti (CM) factor, we express the dispersion
Arnold, Foster, Gao, Gimsa, Huang, Hughes, J. P. Huang, K. W. Yu, Lei, Saito, Sheng, Sukhorukov, Sukhorukov, Y. T. C. Ko, Zimmermann   +14 more
core   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Molecular Electroporation and the Transduction of Oligoarginines

, 2009
Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis.
Alberts B, Alberts B, Alberts B, Alberts B, Alberts B, Bevers E, Bulte J W, Cahill K, Datta K, Grandmaison P A, Hanke M, Harbour J W, Hosotani R, Kevin Cahill, Kuge O, Mai J C, Mendoza N, Vaara M, Vance J E, Voelker D, Vondrášek J   +20 more
core   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Stochastic model for cell polarity

, 2012
Cell polarity refers to the spatial asymmetry of molecules on the cell membrane. Altschuler, Angenent, Wang and Wu have proposed a stochastic model for studying the emergence of polarity in the presence of feedback between molecules.
Gupta, Ankit
core   +1 more source