Results 271 to 280 of about 322,139 (355)

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Efficient encapsulation of CRISPR-Cas9 RNP in bioreducible nanogels and release in a cytosol-mimicking environment. [PDF]

Discov Nano
Westarp P, Keller T, Brand J, Horvat S, Albrecht K, Beisel C, Groll J.   +6 more
europepmc   +1 more source

Androgenic regulation of ornithine decarboxylase activity in mouse kidney and its relationship to changes in cytosol and nuclear androgen receptor concentrations.

, 1982
Antti Pajunen, Veli Isomaa, Olli A. Jänne, C. Wayne Bardin   +3 more
openalex   +1 more source

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source

Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus

Advanced Science, EarlyView.
In wild‐type of M. oryzae (Guy11), MoPrb1 and MoPep4 are delivered into the vacuole by the retromer complex to mediate protein degradation and selective autophagy. Their proper localization and catalytic functions are essential for the fungal vegetative growth, conidiation and pathogenicity. However, retromer mutations disrupt this transport, impairing
Dingyang Zhang, Jiexiong Hu, Yonghe Hong, Yuping Fan, Minghui Peng, Yakubu Saddeeq Abubakar, Shujing Liang, Nan Jiang, Lili Lin, Xiaohong Pan, Huakun Zheng, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +13 more
wiley   +1 more source

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization. [PDF]

NPJ Vaccines
Zarnegar B, Carow B, Eriksson J, Spennare E, Öhlund P, Akpinar E, Bringeland E, Osterman IL, Lundqvist L, Antti J, Handin N, Helgesson PH, Bankefors J, Lövgren Bengtsson K, Sellin ME, Palm AE, Stertman L, Lunderius Andersson C.   +17 more
europepmc   +1 more source

Electrochemistry as a Tool for Redox‐Based Bio‐Information Processing

Advanced Science, EarlyView.
Redox is a modality that is native to biology and accessible to electronics through electrochemistry. Imposed electronic inputs are transduced into redox signals that can probe for bio‐information or actuate biological responses. Measured electronic output responses are analyzed to reveal actionable information.
Eunkyoung Kim, Chen‐yu Chen, Fauziah Rahma Zakaria, Dana Motabar, Mijeong Kang, Deanna L. Kelly, Alessandra Napolitano, William E. Bentley, Gregory F. Payne   +8 more
wiley   +1 more source

Divergent host-pathogen interactions in neurolisteriosis: cytosolic replication vs. phagosomal dormancy of Listeria monocytogenes in CNS macrophages. [PDF]

Acta Neuropathol
Tavares-Gomes L, Polidori M, Monney C, Neuhaus G, Vidondo B, Witz G, Hemphill A, Oevermann A.   +7 more
europepmc   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Control of Snail1 protein stability by post-translational modifications: the basis for a complex regulation of Snail1 function. [PDF]

Int J Biol Sci
García de Herreros A.
europepmc   +1 more source