Results 281 to 290 of about 322,139 (355)

Illuminating Tau Aggregates: Multiscale Approaches for Detection, Imaging, and Understanding

Aggregate, EarlyView.
This review presents recent advances in molecular imaging of tauopathies, focusing on tau aggregation mechanisms, structural polymorphism, and imaging strategies. It highlights the development of tau‐selective fluorescent probes and PET tracers and explores emerging techniques such as cryo‐EM and super‐resolution imaging, offering a multiscale ...
Kaustubh R. Bhuskute, Jiayi Fan, Amandeep Kaur   +2 more
wiley   +1 more source

Papaver S-determinants trigger an integrated network of mitochondrially derived ROS and disruption of energy metabolism in incompatible pollen tubes

Wang L, Hsiao A, Carli J, Raza A, Lin Z, Arnaud D, Davies JM, Franklin-Tong VE, Smirnoff N, Bosch M.   +9 more
europepmc   +1 more source

Analysis of mitochondrial Complex I activity and ATP hydrolysis capacity of ATP synthase in developing rat brains using frozen tissues. [PDF]

MicroPubl Biol
Yao PJ, Munk R, Gorospe M, Kapogiannis D.   +3 more
europepmc   +1 more source

The Role of SLC39A8.p.(Ala391Thr) in Schizophrenia Symptom Severity and Cognitive Ability: Cross‐Sectional Studies of Schizophrenia and the General UK Population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia‐
Sophie E. Smart, Sophie E. Legge, Eilidh Fenner, Antonio F. Pardiñas, Grace Woolway, Amy J. Lynham, Valentina Escott‐Price, Jeremy Hall, Lawrence Wilkinson, Peter Holmans, Michael C. O'Donovan, Michael J. Owen, James T.R. Walters   +12 more
wiley   +1 more source

TAS-seq enables subcellular single-stranded adenosine profiling by signal peptide-assisted adenosine deamination. [PDF]

Cell Rep Methods
Wang L, Zhou Y, Yu Z, Wu P, Lu Z, Ma L.
europepmc   +1 more source

A Drosophila model of prion disease and its metabolic changes in the brain

Animal Models and Experimental Medicine, EarlyView.
We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang, Zhixin Sun, Pei Wen, Mengyang Zhao, Yuheng He, Fengting Gou, Jingjing Wang, Qing Fan, Xueyuan Li, Tianying Ma, Xiaoyu Wang, Wen Li, Sen Chen, Deming Zhao, Lifeng Yang   +14 more
wiley   +1 more source

ATP Supply from Cytosol to Mitochondria Is an Additional Role of Aerobic Glycolysis to Prevent Programmed Cell Death by Maintenance of Mitochondrial Membrane Potential. [PDF]

Metabolites
Sawai A, Taniguchi T, Noguchi K, Seike T, Okahashi N, Takaine M, Matsuda F.   +6 more
europepmc   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Arginyltransferase1 drives a mitochondria-dependent program to induce cell death. [PDF]

Cell Death Dis
Kumar A, O'Shea CR, Yadav VK, Kandasamy G, Moorthy BT, Ambrose EA, Mulati A, Fontanesi F, Zhang F.   +8 more
europepmc   +1 more source

Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease

Annals of Neurology, EarlyView.
Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias, Siiri Sarv, Nathalie Bonello‐Palot, Laura Carrera‐García, Carlos Ortez, Jesica Expósito‐Escudero, Delia Yubero, Jordi Muchart, Emilien Delmont, Eve Õiglane‐Shlik, Teele Meren, Sanna Puusepp, Ülle Murumets, Gajja S. Salomons, Bjarne Udd, Liis Väli, Lara Cantarero, Carsten G. Bönnemann, Andrés Nascimento, Santiago Ramón‐Maiques, Katrin Õunap, Janet Hoenicka, Daniel Natera‐de Benito, Francesc Palau   +23 more
wiley   +1 more source