Results 31 to 40 of about 602,582 (313)

Microgramma vacciniifolia frond lectin (MvFL) exhibits antitumor activity against sarcoma 180 in mice

Phytomedicine Plus, 2021
In this study, we evaluated the antitumor activity of a lectin from Microgramma vacciniifolia frond (MvFL) in sarcoma 180-bearing mice. First, the in vitro cytotoxicity of MvFL on sarcoma 180 cells was evaluated.
Leydianne Leite de Siqueira Patriota, Dalila de Brito Marques Ramos, Yasmym Araújo Silva, Angela Caroline Lima Amorim dos Santos, Maria Taís de Moura Fontes Araújo, Jéssica de Santana Brito, Diego José Lira Torres, Alisson Macário de Oliveira, Diego César Nunes da Silva, Vírginia Maria Barros de Lorena, Patrícia Maria Guedes Paiva, Rosemairy Luciane Mendes, Thiago Henrique Napoleão   +12 more
doaj   +1 more source

Activity Of Cytotoxic Lymphocytes In Patients With Preeclampsia

Interdisciplinary Approaches to Medicine, 2020
With preeclampsia, the average levels of biochemical parameters in mild and severe form did not differ significantly from those in the group with uncomplicated preeclampsia of pregnancy. There is a tendency to a decrease in total protein and an increase in bilirubin, creatinine, urea, and blood trans-ferases as it becomes heavier.
A.M. Kurmanova, B.K. Amanzholova, N.V. Kravtsova   +2 more
openaire   +4 more sources

Cytotoxic Activity of Quassinoids from

Natural Product Communications, 2010
Twenty-four quassinoids isolated from Eurycoma longifolia Jack were investigated for their cytotoxicity against a panel of four different cancer cell lines, which includes three murine cell lines [colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma ...
Katsunori Miyake, Feng Li, Yasuhiro Tezuka, Suresh Awale, Shigetoshi Kadota   +4 more
doaj   +1 more source

Cytotoxic activity of Origanum dictamnus

Fitoterapia, 2007
Several extracts of Origanum dictamnus, an endemic plant of Greece growing only in the island of Crete and the bioassay-directed isolated ursolic acid, were tested in vitro against the P388 (murine leukemia) and the human bronchial epidermoid cancer NSCLC-N6 (non small cell lung cancer) cell lines.
Chinou, I., Liolios, C., Moreau, D., Roussakis, C.   +3 more
openaire   +3 more sources

Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived Streptomyces sp. HDN150000

Marine Drugs
Three new structures named naphpyrone I–K (1–3) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived Streptomyces sp. HDN155000.
Xiaoting Zhang, Falei Zhang, Wenxue Wang, Xingtao Ren, Tianjiao Zhu, Qian Che, Dehai Li, Guojian Zhang   +7 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

New N-Benzenesulfonylguanidine Derivatives and Their Selective Growth Inhibition of Human Breast Cancer Cell Line MCF-7 and Colon Carcinoma HCT-116

Medical Sciences Forum, 2022
Our previous research proved that benzenesulfonylguanidine derivatives display significant cytotoxic activity against human cancer cells. Here, we describe new 1-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)guanidines with cytotoxic activity against HCT-
Aneta Pogorzelska, Jarosław Sławiński, Anna Kawiak   +2 more
doaj   +1 more source

Cytotoxicity and antiangiogenic activity of grandisin

Journal of Pharmacy and Pharmacology, 2009
Abstract Objectives The antitumoural properties of grandisin, a tetrahydrofuran neolignan from Piper solmsianum, were investigated by in-vitro and in-vivo assays using the Ehrlich ascites tumoural (EAT) model. Methods Viability of the
Marize C, Valadares, Isabel Crhistyna Teles, de Carvalho, Luiz, de Oliveira Junior, Marcelo de Sousa, Vieira, Polyana Lopes, Benfica, Flávio Silva, de Carvalho, Lorenna Vieira Silva, Andrade, Eliana Martins, Lima, Massuo Jorge, Kato   +8 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source