Results 61 to 70 of about 871,555 (308)

Selective Cytotoxic Activity of Scutellaria Species

Proceedings, 2017
The genus Scutellaria (Labiatae) is represented by 25 species in Turkish flora. Some of Scutellaria species are used as tonic, wound healing, hemostatic, antioxidant and antitumor in the world.
Zeynep Dogan, Iclal Saracoglu
doaj   +1 more source

Antimycobacterial and cytotoxicity activity of microcystins [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
The present work aimed to evaluate the antimycobacterial activity and cytotoxicity of Microcystis aeruginosa toxins, the MC-LR variant and purified extract of [D-Leu(1)] microcystin-LR.The antimicrobial activity of M. aeruginosa extract and microcystin was evaluated by resazurin microtiter assay against Mycobacterium tuberculosis, M.
Ramos, Daniela Fernandes, Matthiensen, Alexandre, Colvara, Wilson, Votto, Ana Paula Souza de, Trindade, Gilma Santos, Silva, Pedro Eduardo Almeida da, Yunes, João Sarkis   +6 more
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

(5Z,9Z)-14-[(3,28-Dioxoolean-12-en-28-yl)oxy]tetradeca-5,9-dienoic Acid with Cytotoxic Activity

Molbank
For the first time, a synthetic analogue of natural (5Z,9Z)-dienoic acid has been synthesized in the form of a hybrid molecule containing a fragment of oleanolic acid and (5Z,9Z)-tetradeca-5.9-dienedicarboxylic acid, synthesized using a new reaction of ...
Regina A. Tuktarova, Lilya U. Dzhemileva, Usein M. Dzhemilev   +2 more
doaj   +1 more source

Generation of virus-specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus-specific cytotoxic T cells [PDF]

, 1979
H-2-restricted cytotoxic T cells specific for Sendai virus were generated in vitro in a primary response from normal mouse lymphocytes cultured in the presence of infective as well as inactivated Sendai virus. Antigen-presenting cells of different origin,
Andersson, Burakoff, Butchko, Cantor, Cantor, Cerottini, Cerottini, Dunlop, Engers, Engers, Ennis, Ertl, Ertl, Finberg, Gething, Hapel, Hayry, Julius, Jung, Kessel, Kirchner, Koszinowski, Koszinowski, Koszinowski, Lafferty, Levy, Lightbody, McKenzie, Palmer, Parker, Pfitzenmaier, Plate, Röllinghoff, Schrader, Shen, Simon, Wagner, Wagner, Wiktor, Zinkernagel, Zinkernagel, Zweerinck   +41 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues

Acta Chimica Slovenica, 2020
A series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps.
Asligul Kucukdumlu, Meral Tunçbilek, Ebru Bilget Guven, Rengul Cetin Atalay   +3 more
doaj   +1 more source

Uji Aktivitas Sitotoksik Kombinasi Ekstrak Etanol Daun Kemangi (Ocimum Sanctum L.) Dan Lengkuas (Alpinia Galanga)Terhadap Sel MCF-7 [PDF]

, 2018
Breast cancer is one cause of death in the world in women, including Indonesia. Ocimum sanctum L. and Alpinia galanga are plants that have the potential to be used as an alternative to cancer treatment. The Ocimum sanctum L.
, Maryati, Ph.D., Apt, Puspasari, Helvira   +1 more
core  

Bright spots in the darkness of cancer: A review of starfishes-derived compounds and their anti-tumor action [PDF]

, 2019
The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable.
Arizza V., Lazzara V., Luparello C., Mauro M., Vazzana M.   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source