Results 61 to 70 of about 602,582 (313)

Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection

, 2001
Cytotoxic T lymphocytes (CTLs) play a vital part in controlling viral replication during human viral infections. Most studies in human infections have focused on CTL specificities in chronic infection and few data exist regarding the specificity of the ...
Sekaly, R.P., Eldridge, RL, Kalams, SA, Altfeld, M.A., He, S, Phillips, M.N., He, S., Phillips, MN, Tang, Y, Eldridge, R.L., Walker, B.D., Nguyen, T, Addo, MM, Muckerjee, J.S., Rosenberg, ES, Walker, BD, Nguyen, T.T., Bunce, M, Addo, M.M., Kalams, S.A., Mukherjee, JS, Rosenberg, E.S., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Altfeld, MA, Sekaly, RP, Tang, Y., Bunce, M.   +29 more
core   +1 more source

The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo [PDF]

, 2005
Background The integrin CD11c is known as a marker for dendritic cells and has recently been described on T cells following lymphotropic choriomeningitis virus infection, a systemic infection affecting a multitude of organs.
Nina Peters, Doths, Sandra, Peter JM Openshaw, Jürgen Schwarze, Openshaw, Peter J M, Wang, HW, Peters, N, Wang Hongwei, Koerner-Rettberg, C, Schwarze Jürgen, Beyer, Marc, Koerner-Rettberg, Cordula, Beyer Marc, Openshaw Peter JM, Marc Beyer, Koerner-Rettberg Cordula, Schwarze, J, Cordula Koerner-Rettberg, Doths, S, Peters Nina, Doths Sandra, Beyer, M, Hongwei Wang, Schwarze, Jürgen, Openshaw, PJ, Peters, Nina, Sandra Doths, Wang, Hongwei   +27 more
core   +1 more source

Measurement of cytotoxic activity in experimental cancer [PDF]

Journal of Clinical Laboratory Analysis, 2004
AbstractSeveral tumor cell systems have been developed for investigating the cytotoxic activity of different substances. The Ehrlich ascytic tumor (EAT) has been studied extensively and used to increase our comprehension of immunotherapy (Yamamoto and Naraparaju. Cancer Res 57:2187–2192, 1997).
Nayara Delgado, Andre, Décio Sabbatini, Barbosa, Egberto, Munhoz, Dirceu, Estevão, Rubens, Cecchini, Maria Angelica Ehara, Watanabe   +5 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Intestinal Intraepithelial Lymphocytes Exert Potent Protective Cytotoxic Activity During an Acute Virus Infection

, 2000
After systemic infection of mice with 104 PFU of lymphocytic choriomeningitis virus (LCMV), infected cells are detected simultaneously in various organs, including spleen and intestinal mucosa.
Müller, Stefan, Christoph Mueller, Mueller, Christoph, Stefan Müller, Bühler-Jungo, Myriam, Myriam Bühler-Jungo   +5 more
core   +1 more source

Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives

Brazilian Journal of Pharmaceutical Sciences
The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential ...
Saulo Feheiberg Pinto Braga, Nayara Cristina Fonseca, Jonas Pereira Ramos, Elaine Maria de Souza-Fagundes, Renata Barbosa de Oliveira   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluation of Chemical Composition, Antibacterial, Antifungal, and Cytotoxic Activity of Laurus nobilis L Grown in Saudi Arabia

, 2019
Present study aimed to evaluate the chemical composition, antibacterial, antifungal, and cytotoxic activity of Laurus nobilis grown in Tabuk region of Saudi Arabia. Dried leaves of L. nobilis were extracted with various solvent with increasing polarities.
Noorah Al Kubaisi, Nadine MS Moubayed, Gadah Albasher, Nadeen N. Al-Meghailaith, Humaira Rizwana   +4 more
core   +1 more source

Cytotoxic Activity of Iraqi Cressa Cretica

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2019
Cressa cretica Fam: Convolvulaceae (morning glory). These plants are native to the tropical and subtropical areas of the world. Nutritional analysis provide it to be a potential source of minerals, energy, carbohydrate, alpha-tocopherol, edible oil ...
Farah fawzi, Monther F. Mahdi, Ibrahim S. Abaas   +2 more
doaj   +1 more source