Results 81 to 90 of about 12,300,004 (314)

Selective Cytotoxic Activity of Prodigiosin@halloysite Nanoformulation

Frontiers in Bioengineering and Biotechnology, 2020
Prodigiosin, a bioactive secondary metabolite produced by Serratia marcescens, is an effective proapoptotic agent against various cancer cell lines, with little or no toxicity toward normal cells.
Ivan Guryanov, Ekaterina Naumenko, Farida Akhatova, Giuseppe Lazzara, Giuseppe Lazzara, Giuseppe Cavallaro, Giuseppe Cavallaro, Läysän Nigamatzyanova, Rawil Fakhrullin   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

ESTUDO FITOQUÍMICO, ATIVIDADE ANTIMICROBIANA E CITOTÓXICA DE ESPÉCIMES DE Leonotis nepetifolia L. R. (Br)

Química Nova, 2016
Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol ...
Ana P. Oliveira, Amanda L. Guimarães, Alessandra G. M. Pacheco, Camila S. Araújo, Raimundo G. Oliveira Júnior, Érica M. Lavor, Mariana G. Silva, Edigênia C. C. Araújo, Rosemairy L. Mendes, Larissa A. Rolim, Marcília P. Costa, Henrique C. L. Farias, Cláudia do Ó Pessoa, Norberto P. Lopes, Lucas M. M. Marques, Jackson R. G. S. Almeida   +15 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cytotoxic Activity of Some Lupeol Derivatives

Natural Product Communications, 2016
The synthesis of 3- O -acyl derivatives of lupeol is presented, as well as lupenone and the oxime of lupenone. The obtained derivatives were subjected to the MTT test in order to evaluate their cytotoxic activity toward HeLa, KB, MCF-7 and A-549 cell ...
Barbara Bednarczyk-Cwynar, Tomasz Wiȩcaszek, Piotr Ruszkowski   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

HPLC Analysis and Cytotoxic Activity of

Natural Product Communications, 2012
The extracts of five Cambodian medicinal plants ( Aganosma marginata , Dracaena cambodiana , Harrisonia perforata , Hymenodictyon excelsum and Vernonia cinerea ) were evaluated in vitro for their cytotoxic activity against HT29 colon adenocarcinoma cells
Mom Khay, Phirom Toeng, Valérie Mahiou-Leddet, Fathi Mabrouki, Kim Sothea, Evelyne Ollivier, Riad Elias, Sok-Siya Bun   +7 more
doaj   +1 more source

Cytotoxic Activity of Some Azole Derivatives

Asian Pacific Journal of Cancer Biology, 2018
Azole derivatives are an important class of compounds in medicinal chemistry with a wide variety of biological activities. We previously described synthesis and antimicrobial evaluations of some new Azole derivatives.
Zeinab Faghih, Zahra Rezaei, Akram Jamshidzade, Aboozar Keshavarz, Soghra Khabnadideh   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source