Results 81 to 90 of about 602,582 (313)

HPLC Analysis and Cytotoxic Activity of

Natural Product Communications, 2012
The extracts of five Cambodian medicinal plants ( Aganosma marginata , Dracaena cambodiana , Harrisonia perforata , Hymenodictyon excelsum and Vernonia cinerea ) were evaluated in vitro for their cytotoxic activity against HT29 colon adenocarcinoma cells
Mom Khay, Phirom Toeng, Valérie Mahiou-Leddet, Fathi Mabrouki, Kim Sothea, Evelyne Ollivier, Riad Elias, Sok-Siya Bun   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The reproductive biology and cytotoxic activity of Persicaria chinensis (L.) H. gross var. chinensis (polygonaceae) / Wong Min May [PDF]

, 2012
Persicaria chinensis var. chinensis is a native variety in Malaysia and found in the tropics growing in lowland and lower montane forests. Growth habit and morphological differences were observed between the highland and lowland varieties.
Wong, Min May
core  

Inactivation of the antibacterial and cytotoxic properties of silver ions by biologically relevant compounds [PDF]

, 2014
There has been a recent surge in the use of silver as an antimicrobial agent in a wide range of domestic and clinical products, intended to prevent or treat bacterial infections and reduce bacterial colonization of surfaces. It has been reported that the
Jenkins A. Tobias A., Mulley, Geraldine, Geraldine Mulley, Waterfield, Nicholas R., A Tobias A Jenkins, Jenkins, A. Tobias A., Nicholas R Waterfield, Mulley Geraldine, Waterfield Nicholas R.   +8 more
core   +1 more source

Cytotoxic Activity of Some Lupeol Derivatives

Natural Product Communications, 2016
The synthesis of 3- O -acyl derivatives of lupeol is presented, as well as lupenone and the oxime of lupenone. The obtained derivatives were subjected to the MTT test in order to evaluate their cytotoxic activity toward HeLa, KB, MCF-7 and A-549 cell ...
Barbara Bednarczyk-Cwynar, Tomasz Wiȩcaszek, Piotr Ruszkowski   +2 more
doaj   +1 more source

Cytotoxic Activity of Some Azole Derivatives

Asian Pacific Journal of Cancer Biology, 2018
Azole derivatives are an important class of compounds in medicinal chemistry with a wide variety of biological activities. We previously described synthesis and antimicrobial evaluations of some new Azole derivatives.
Zeinab Faghih, Zahra Rezaei, Akram Jamshidzade, Aboozar Keshavarz, Soghra Khabnadideh   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones

, 2007
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon [gamma] (IFN[gamma]), IL-2, IL-3,
Kenji Tadokoro, Hideya Sato, Masahiro Satake, Hitoshi Okazaki, Motoko Nishimura   +4 more
core  

Cytotoxic activity of some Tanzanian medicinal plants

, 2006
Thirty-three aqueous methanolic extracts obtained from thirty plant species, belonging to seventeen families were screened for cytotoxic activity against HeLa (Human cervical carcinoma) cells.
Ngassapa, OD, Kamuhabwa, A, DKB Runyoro, A Kamuhabwa, OD Ngassapa, P De Witte, Runyoro, DKB, de Witte, P   +7 more
core   +1 more source

Immunomodulatory Effects of Modified Colostrum, Whey, and Their Combination With Other Natural Products: Effects on Natural Killer Cells

Current Therapeutic Research
Objectives: Natural killer (NK) cells are important immune system effector cells providing innate defenses against intracellular infections, including viral infections, immune surveillance, and cancer immunoediting.
Xuesheng Han, MS, David Vollmer, MS, Xuefei Yan, MS, Yahong Zhang, MS, Mingfa Zang, MPVM, Chenfei Zhang, MS, Catherine M. Sherwin, MS, Elena Y. Enioutina, MS   +7 more
doaj   +1 more source