Results 81 to 90 of about 871,555 (308)

Selective Cytotoxic Activity of Prodigiosin@halloysite Nanoformulation

Frontiers in Bioengineering and Biotechnology, 2020
Prodigiosin, a bioactive secondary metabolite produced by Serratia marcescens, is an effective proapoptotic agent against various cancer cell lines, with little or no toxicity toward normal cells.
Ivan Guryanov, Ekaterina Naumenko, Farida Akhatova, Giuseppe Lazzara, Giuseppe Lazzara, Giuseppe Cavallaro, Giuseppe Cavallaro, Läysän Nigamatzyanova, Rawil Fakhrullin   +8 more
doaj   +1 more source

Biological activities of ethanolic extracts from deep-sea antarctic marine sponges [PDF]

, 2013
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth ...
Ambrožič Avguštin, Jerneja, Batista, Urška, Janussen, Dorte, Kauferstein, Silke, Kosmina, Rok, Mebs, Dietrich, Sepčić, Kristina, Strugar, Gašper, Turk, Tom, Čivović, Sandra   +9 more
core   +3 more sources

Inherited defects in lymphocyte cytotoxic activity

Immunological Reviews, 2010
Summary:  The granule‐dependent cytotoxic activity of lymphocytes plays a critical role in the defense against virally infected cells and tumor cells. The importance of this cytotoxic pathway in immune regulation is evidenced by the severe and often fatal condition, known as hemophagocytic lymphohistiocytic syndrome (HLH) that occurs in mice and humans
Jana, Pachlopnik Schmid, Jana P, Schmid, Marjorie, Côte, Mickaël M, Ménager, Agathe, Burgess, Nadine, Nehme, Gaël, Ménasché, Alain, Fischer, Geneviève, de Saint Basile   +8 more
openaire   +3 more sources

Titanocene Difluorides with Improved Cytotoxic Activity [PDF]

Inorganic Chemistry, 2010
Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.
Eger, Silvia, Immel, Timo, Groth, Ulrich, Huhn, Thomas, Claffey, James, Müller-Bunz, Helge, Tacke, Matthias   +6 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

New trends for metal complexes with anticancer activity [PDF]

, 2008
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is,
Ang, Ang, Barnard, Barnes, Bednarski, Bergamo, Bregman, Calderone, Casini, Debreczeni, Dixon, Dyson, Failes, Feazell, Guo, Habtemariam, Hall, Hambley, Hannon, Harris, Heringova, Hillard, Hotze, James, Jung, Komeda, Liu, Lutterman, MacDiarmid, Mackay, Mackay, McNae, Meggers, Milacic, Noor, Oleksi, Orvig, Ott, Pascu, Peacock, Peter J Sadler, Pieter CA Bruijnincx, Reed, Schatzschneider, Schlawe, Scolaro, Smalley, Sun, Thompson, Timerbaev, Urig, Urig, van Zutphen, Wang, Weidt, Yan, Yang   +56 more
core   +1 more source

Cytotoxic activity of selected Nigerian plants

African Journal of Traditional, Complementary and Alternative Medicines, 2010
Cancer is one of the most prominent human diseases which has stimulated scientific and commercial interest in the discovery of new anticancer agents from natural sources. The current study investigates the cytotoxic activity of ethanolic extracts of sixteen Nigerian plants used locally for the treatment of cancer using the MTT assay on the HeLa cell ...
Sowemimo, A., Venter, M. van de, Baatjies, L., Koekemoer, T.   +3 more
openaire   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

ESTUDO FITOQUÍMICO, ATIVIDADE ANTIMICROBIANA E CITOTÓXICA DE ESPÉCIMES DE Leonotis nepetifolia L. R. (Br)

Química Nova, 2016
Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol ...
Ana P. Oliveira, Amanda L. Guimarães, Alessandra G. M. Pacheco, Camila S. Araújo, Raimundo G. Oliveira Júnior, Érica M. Lavor, Mariana G. Silva, Edigênia C. C. Araújo, Rosemairy L. Mendes, Larissa A. Rolim, Marcília P. Costa, Henrique C. L. Farias, Cláudia do Ó Pessoa, Norberto P. Lopes, Lucas M. M. Marques, Jackson R. G. S. Almeida   +15 more
doaj   +1 more source

ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.

, 2001
The enzyme-linked immunospot technique (ELISPOT) relies on the visualization of cytokine secretion by individual T cells following in vitro stimulation with antigen. This assay has been developed and standardized for the quantitative detection of antigen-
Carvalho, LH, Hafalla, JC, Zavala, F
core   +1 more source