Results 91 to 100 of about 602,582 (313)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Cytotoxic Activity of Croton gibsonianus Nimm. Grah

, 2013
The present study was designed to investigate the cytotoxic activity ofmethanol extract of Croton gibsonianus Nimm. Grah (Euphorbiaceae) leavesby brine shrimp lethality bioassay. The powdered leaf material was extractedwith methanol.
Vinayaka, KS, Raghavendra, HL, Prashith, KTR   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Synthesis and cytotoxic activity of N-acetylated triindolylmethanes

, 2003
Triindolylmethanes or N-acetylated triindolylmethanes were synthesized with high yields by treating indoles with indole-3-carboxaldehydes in acetic acid and acetic anhydride.
Guang, B, Li, J, Li, J, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Wang, LB, Li, BG, Zhang, GL   +5 more
core  

Cytotoxic sesquiterpenes from Ligularia platyglossa

, 2008
Four sesquiterpene lactones including an eremophilenolide dimer, named as biligulaplenolide, 1, 8β-hydroxy-1-oxo-(14α,15α eremophil-7(11),9(10)-dien-12,8α-olide, 2, 1-hydroxy-2-oxo-(14α,15α eremophil-1(10),7(11),8(9)-trien-12,8-olide, 3, 4α,8β,9α ...
Qi, H.Y., Liu, J.Q., Zhang, M., Wang, Z., Bligh, S.W.A., Zhang, C.-F., Bashall, A.   +6 more
core   +1 more source

Chemical characterization of polyphenol extracts from Andean and industrial Solanum tuberosum tubers and their cytotoxic activity on human hepatocarcinoma cells [PDF]

, 2017
Background: Polyphenols are plant metabolites that have been largely studied for their beneficial effect on human health. Potato is one of the most important crops worldwide and is a relevant source of human dietary nutrients and antioxidants ...
Martinez, María Julia, Barbini, Luciana, Barbini Luciana, Andreu Adriana Balbina, Andreu, Adriana Balbina, Martinez Maria Julia   +5 more
core   +1 more source

Determination of chemical components of the endemic species Allium turcicum L. plant extract by LC-MS/MS and evaluation of medicinal potentials

Heliyon
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first ...
Polat İpek, Mehmet Nuri Atalar, Ayşe Baran, Mehmet Fırat Baran, Mohammad Mehdi Ommati, Musa Karadag, Murat Zor, Aziz Eftekhari, Mehmet Hakkı Alma, Khaled Zoroufchi Benis, Fidan Nuriyeva, Rovshan Khalilov   +11 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties

Molecules, 2016
In our endeavor towards the development of potent anticancer agents, two different sets of biphenylurea-indolinone conjugates, 5a–s and 8a,b were synthesized.
Wagdy M. Eldehna, Mohamed Fares, Hany S. Ibrahim, Muhammad A. Alsherbiny, Mohamed H. Aly, Hazem A. Ghabbour, Hatem A. Abdel-Aziz   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

New phenanthrene glycosides from Dendrobium denneanum and their cytotoxic activity

, 2013
Five new phenanthrene glycosides, denneanosides A-E (1-5), and one new 9,10-dihydrophenanthrene glycoside, denneanoside F (6) were isolated from the stem of Dendrobium denneanum.
Liu, X, Xi, XJ, Wang, MK, Li, F, Chen, B, Pan, HM, Tang, YX   +6 more
core