Results 71 to 80 of about 602,582 (313)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Madecassic acid – isolated from the medicinal herb Centella asiatica – and its derivatives exhibit cytotoxic activity against the HepG2 liver cancer cell line.
Dung Thi, Nguyen +11 more
core +1 more source
, 2005 Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell responses to such mutants.
Allgaier, R.L. +35 more
core +1 more source
Alkaloids From and Their Cytotoxic Activity
Natural Product Communications, 2019 Zanthoxylum nitidum (Roxb.) DC (Rutaceae) is a traditional medicine used for the treatment of various diseases like toothache, gingivitis, fever, colic vomiting, diarrhea, and cholera.
Thi Hong Van Nguyen +8 more
doaj +1 more source
Selective Cytotoxic Activity of Prodigiosin@halloysite Nanoformulation
Frontiers in Bioengineering and Biotechnology, 2020 Prodigiosin, a bioactive secondary metabolite produced by Serratia marcescens, is an effective proapoptotic agent against various cancer cell lines, with little or no toxicity toward normal cells.
Ivan Guryanov +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
New oxidative derivatives of atractyligenin and their cytotoxic activity
, 2006 ent-Kauranes are naturally occurring diterpenoids isolated from several families, such as Asteraceae and Lamiaceae. These compounds have attracted interest because of their structures and their biological activities as anti-tumorals, anti-HIV and anti ...
BRUNO, Maurizio +4 more
core +1 more source
Endothelial cells as targets for antigen-specific cytotoxic T lymphocytes [PDF]
, 2010 BACKGROUND: In this study we have examined human vascular endothelial cells as targets for antigen-specific cytotoxic T lymphocytes (CTL). Vascular endothelial cells (EC) act as the major interface between blood and tissues and are crucial for the ...
Thommen, Daniela Stefanie
core +1 more source
Química Nova, 2016 Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol ...
Ana P. Oliveira +15 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source