Results 161 to 170 of about 27,071 (267)

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Protective Effect of LGG From Lophatherum Gracile Brongn. on Alcohol‐Injured HepG2 Cells and Exploration of Potential Mechanism

eFood, Volume 7, Issue 2, April 2026.
LGG was separated from L. gracile and its hepatoprotective effect was investigated. LGG significantly reduced the mortality, ROS and MDA content in alcohol‐injured liver cells. LGG up‐regulated 156 mRNAs (63 miRNAs) and down‐regulated 1529 mRNAs (35 miRNAs).
Yi‐Long Ma, Xin Guo, Zheng‐Fang Wu, Qian‐Lan Wu, Jing Li, Tian‐Le Mao, Zhi Li, Ya‐Fang Shang, Kiran Thakur, Zhao‐Jun Wei   +9 more
wiley   +1 more source

How Different Traditional and Modern Coffee Brewing Methods Affect Its Aroma, Chemistry, Health Effects and Safety Attributes?—A Comprehensive Review to Maximize Coffee Brew Quality

eFood, Volume 7, Issue 2, April 2026.
This review article provides a comprehensive analysis of coffee pre‐brewing techniques, focusing on the methodology and key parameters involved in each coffee brewing process. It also summarizes how different brewing methods affect the coffee metabolome, antioxidant levels, aroma, and physicochemical features.
Enas A. El‐Hawary, Hania A. Guirguis, Nik Muhammad Azhar Nik Daud, Mohd Asraf Zainudin, Ahmed Mediani, Mohamed A. Farag   +5 more
wiley   +1 more source

A Narrative Review of Antioxidant, Anti‐Inflammatory, Anti‐Apoptotic, Immunomodulatory, and Anticancer Properties of Rosa damascena Mill.

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Rosa damascena Mill. exhibits a broad spectrum of pharmacological activities mediated by its rich phytochemical profile. The plant enhances antioxidant defenses by increasing endogenous enzymes (CAT, SOD, GSH, GST, GPx, FRAP) and reducing oxidative stress markers (MDA, MPO).
Mahboobeh Ghasemzadeh Rahbardar, Nikta Soltani, Mohammad Hossein Boskabady   +2 more
wiley   +1 more source

Physico‐Nutritional Profiling and Assessment of Proteins as Well as Soluble and Insoluble Phenolic Acids in Gamma Irradiated Wheat Grains Through SWATH‐MS and HPLC Analysis and Their Functionality

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Gamma irradiation (Dmin 650 Gy) proved effective in controlling insect pest infestations in stored wheat grains which otherwise undergo extensive losses during storage. SWATH‐MS based proteomics affirmed integrity of major storage proteins including prolamines and increased extractability of phenolics (soluble free & conjugated) was observed in ...
S. Saxena, S. Kumar, D. K. Maurya, J. Tripathi, J. Kumar, A. B. Hadapad, S. Gautam   +6 more
wiley   +1 more source

Gastrodia elata–Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Gastrodia elata‐Derived Parishin Extracts (GEPE) attenuates aging by modulating oxidative stress, inflammation, apoptosis, and metabolisms, highlighting its potential as a candidate for anti‐aging interventions. ABSTRACT This study investigates the anti‐aging properties of Gastrodia elata‐derived Parishin extracts (GEPE) by exploring its regulatory ...
Zhu Li, Yue Chen, Huihuang Shi, Peng Tang, Xiangui Zhang   +4 more
wiley   +1 more source

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

Rosanoid diterpenoids: structural diversity, classification and biological activities. [PDF]

ADMET DMPK
Ibrahim SRM, Asfour HZ, Mohamed GA, Alhakamy NA, Abdallah HM, Mohamed HM.   +5 more
europepmc   +1 more source

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy

MedComm, Volume 7, Issue 4, April 2026.
In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang, Zikai Dong, Yongfei Wang, Ziyi An, Siyuan Wang, Wei‐Lin Jin   +5 more
wiley   +1 more source

Optimization of Hot and Cold‐Water Extractions of Cistus salviifolius L. for Enhanced Phenolic Content and Antimicrobial Efficacy

ChemistrySelect, Volume 11, Issue 13, 6 April 2026.
This study optimized cold and hot water extractions for maximizing phenolic content and antibacterial activity against S. aureus and P. aeruginosa. Hot water yielded higher total phenolics and were more effective against P. aeruginosa. Conversely, cold water enriched specific ellagitannins (punicalagin and cistusin), showing potent, targeted ...
Atalanti Christou, Alexandra Charilaou, Danae Markou, Nikolaos A. Parisis, Panayiota Piri, Konstantina Stavrou, Andreas G. Tzakos, George Botsaris, Ioannis P. Gerothanassis, Vlasios Goulas   +9 more
wiley   +1 more source