Results 171 to 180 of about 27,071 (267)

Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2‐Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open‐Label, Single‐Arm, Phase IV Study

Asia-Pacific Journal of Clinical Oncology, Volume 22, Issue 2, Page 240-250, April 2026.
A phase IV, single‐arm, open‐label, multicenter study assessing the safety and efficacy of trastuzumab emtansine in Indian patients for the treatment of human epidermal growth factor receptor 2 (HER2)‐positive unresectable locally advanced or metastatic breast cancer who received prior treatment with trastuzumab and a taxane.
Sudeep Gupta, Manish Singhal, Shona Nag, Waseem Abbas, Dinesh Chandra Doval, Hari Goyal, Chirag Shah, Ashish Singh, Radheshyam Naik, Nitesh Rohatgi, Poonam Patil, Shyam Aggarwal, Vinod Raina, Vaibhav Watts   +13 more
wiley   +1 more source

Unregulated use of <i>Artemisia</i> in cancer patients in Libya: an emerging ethical and public health concern. [PDF]

Libyan J Med
Alhudiri I, Ebrahim F, Elzagheid A.
europepmc   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Multiscale Interactome-Guided Prioritization of Candidate Herbs and Active Compounds for Hepatic Cirrhosis Using a Biased Random Walk Algorithm. [PDF]

Curr Issues Mol Biol
Lee JH, Bak SB, Lee WY, Kim YK.
europepmc   +1 more source

Medicinal Herbs and Probiotics: Antioxidant Activities for Damaged DNA Protection and Cytotoxicity toward Cancer Treatment

Oxidative stress is an imbalance between oxidation and antioxidant responses caused by the accumulation of free radicals in the body. Cells produce free radicals that cause oxidative damage such as aging, atherosclerosis, arthritis, cancer, and neurological diseases.
openaire   +1 more source

Acacetin Alleviates Loperamide‐Induced Functional Constipation by Inhibiting P53‐Mediated Apoptosis in Colonic Epithelial Cells

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
Acacetin, a compound from the traditional Chinese medicine Yunweiling, alleviates functional constipation by inhibiting P53‐mediated apoptosis in colonic epithelial cells. In mouse models and cell experiments, acacetin improved gastrointestinal motility and protected colon tissue by suppressing P53 activation and maintaining Akt1 signaling.
Xia Chen, Ting Yang, Yao Huang, Yaping Yang, Xian Li, Yaowei Ma, Haobai Long, Ding Liao, Peng Zhang, Weibo Wen   +9 more
wiley   +1 more source

Phytochemical Composition and Therapeutic Potential of <i>Ludwigia adscendens</i>: A Narrative Review. [PDF]

ScientificWorldJournal
Easha TM, Jyoti FH, Afrin F, Nasrin M.
europepmc   +1 more source

Evaluating the Efficacy of Polyphenol‐Enriched Plant Extracts and Pathway Modulators in the Bone Marrow to Suppress Breast Cancer Progression

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
The combined therapy decreased inflammatory and angiogenic signaling and altered bone marrow cell profiles linked to tumor dormancy, indicating a potential approach to limit disease progression and reduce relapse risk in breast cancer. ABSTRACT Disseminated tumor cells (DTCs) in the bone marrow can survive in a dormant state and later reawaken to drive
Hayarpi Javrushyan, Gayane Petrosyan, Marika Mróz, Barbara Kusznierewicz, Yem Alharithi, Mikayel Ginovyan, Alina Maloyan, Nikolay Avtandilyan   +7 more
wiley   +1 more source

Risks, Benefits, and Molecular Targets of Fenugreek Administration in the Treatment of Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Vittal M, Menegassi B, Vinciguerra M.
europepmc   +1 more source

Chrysanthemum morifolium extract protects HT22 cells from oxidative stress and enhances sleep via GABAergic modulation: contribution of luteolin‐7‐glucoside

Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2100-2110, 15 March 2026.
Abstract BACKGROUND Chrysanthemum morifolium has long been utilized in traditional medicine for its antioxidant and sedative properties, yet its potential in sleep regulation and neuroprotection against oxidative stress remains underexplored. This study investigates the antioxidant and sleep‐enhancing effects of C.
Hyeongyeong Kim, Seok Hyun Chung, Singeun Kim, Sooil Ko, Jae‐Chul Jung, Hyun Jung Lee, Hyowon Lee   +6 more
wiley   +1 more source