Results 1 to 10 of about 1,422,099 (294)
Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1) [PDF]
Scientific Reports, 2022 Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of solid cancers ...
Nerea Allende-Vega +14 more
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Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells [PDF]
Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. [PDF]
Immunity, 2021 Immune cells identify and destroy tumors by recognizing cellular traits indicative of oncogenic transformation. In this study, we found that myocardin-related transcription factors (MRTFs), which promote migration and metastatic invasion, also sensitize ...
Tello-Lafoz M +14 more
europepmc +2 more sources
Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits [PDF]
Journal of Veterinary Research, 2023 Lagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly
Niedźwiedzka-Rystwej Paulina +1 more
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Runx3-mediated transcriptional program in cytotoxic lymphocytes. [PDF]
PLoS ONE, 2013 The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still
Joseph Lotem +5 more
doaj +2 more sources
Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. [PDF]
Cell Death Dis, 2017 Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells.
Bhat P +3 more
europepmc +2 more sources
Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges. [PDF]
Br J Pharmacol, 2017 Kyaw T +5 more
europepmc +2 more sources
Frontiers in Immunology, 2021 Tissue-resident memory (TRM) CD8+ T-cells play a crucial role in the protection against influenza infection but remain difficult to elicit using recombinant protein vaccines.
Judith Del Campo +13 more
doaj +1 more source
Медицинская иммунология, 2020 We studied sex differences lymphocytes subpopulations of peripheral blood in adult C57Bl/6 mice during acute and chronic colitis, induced with 1% DSS. We measured subpopulations of lymphocytes with flow cytometry.
O. V. Makarova +3 more
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Инфекция и иммунитет, 2016 Acute infectious mononucleosis is a widespread viral disease, which most often manifests in childhood. The development of acute infectious mononucleosis is accompanied by the change of the CD4+/CD8+ T-lymphocytes ratio and the increase of the virus ...
E. N. Filatova +5 more
doaj +1 more source