Results 11 to 20 of about 1,422,099 (294)

CLINICAL LIVER MORPHOLOGY: CYTOTOXIC LYMPHOCYTES

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
Background. The liver is the organ of the immune system, in which various populations of lymphocytes are representatives of congenital and acquired immunity: NK cells, NKT cells, LGL cells, CD8 + (CTL) cells that participate in cytotoxic reactions ...
Tsyrkunov V. M., Andreev V. P., Prokopchik N. I., Kravchuk R. I .   +3 more
doaj   +1 more source

High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy (CACI-IMPACT Platform)

Frontiers in Immunology, 2019
Adoptive cell transfer against solid tumors faces challenges to overcome tumor microenvironment (TME), which plays as a physical barrier and provides immuno-suppressive conditions.
Dohyun Park, Kyungmin Son, Yunchan Hwang, Jihoon Ko, Younggyun Lee, Junsang Doh, Noo Li Jeon, Noo Li Jeon, Noo Li Jeon, Noo Li Jeon   +9 more
doaj   +1 more source

In vitro Generation of Cytotoxic T Cells With Potential for Adoptive Tumor Immunotherapy of Multiple Myeloma

Frontiers in Immunology, 2019
Multiple myeloma is a life-threatening hematological malignancy, which is rarely curable by conventional therapies. Immunotherapy, using tumor antigen-specific, cytotoxic T-lymphocytes, may represent an alternative or additional treatment for multiple ...
Wafaa S. Khalaf, Wafaa S. Khalaf, Mamta Garg, Yehia S. Mohamed, Yehia S. Mohamed, Cordula M. Stover, Michael J. Browning, Michael J. Browning   +7 more
doaj   +1 more source

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Cellular & Molecular Immunology, 2020
In December 2019, a novel coronavirus was first reported in Wuhan, China. It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for coronavirus disease 2019 (COVID-19).
M. Zheng, Yong Gao, Gang Wang, Guobin Song, Siyu Liu, Dandan Sun, Yuanhong Xu, Z. Tian   +7 more
semanticscholar   +1 more source

The metabolism of cells regulates their sensitivity to NK cells depending on p53 status

Scientific Reports, 2022
Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymphocytes, which
Sana Belkahla, Joaquin Marco Brualla, Alexis Fayd’herbe de Maudave, Paolo Falvo, Nerea Allende-Vega, Michael Constantinides, Abrar Ul Haq Khan, Lois Coenon, Catherine Alexia, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Wissem Mnif, Javier Hernandez, Alberto Anel, Martin Villalba   +16 more
doaj   +1 more source

AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.

Current Opinion in Immunology, 2023
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses.
Diana Schnoegl, Angela Hiesinger, N. Huntington, D. Gotthardt   +3 more
semanticscholar   +1 more source

Investigation of gadobutrol-induced Sister Chromatid Exchange in G0 phase and circulating human lymphocytes [PDF]

Arhiv za farmaciju
Gadobutrol (Gadovist®) is a macrocyclic, extracellular gadolinium-based contrast agent widely used in magnetic resonance imaging. This study aims to assess the genotoxic and cytotoxic potential of gadobutrol in human G0 phase lymphocytes and circulating ...
Cobanoglu Hayal, Cayir Akin
doaj   +1 more source

Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes

Frontiers in Immunology, 2020
Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in
Marwa Sleiman, David R. Stevens, Praneeth Chitirala, Jens Rettig   +3 more
doaj   +1 more source

Production of CD87 Antigen-Specific CAR-T Lymphocytes and Assessment of Their In Vitro Functional Activity

Клиническая онкогематология, 2022
Aim. To generate anti-CD87 CAR-T lymphocytes and to assess their in vitro functional activity. Materials & Methods. Т-lymphocytes isolated from healthy donor peripheral blood were transduced with the anti-CD87-CAR, T2A, and FusionRed gene coding ...
M. V. Neklesova, Sergei Vladimirovich Smirnov, A. A. Shatilova, K. A. Levchuk, A. E. Ershova, S. A. Silonov   +5 more
doaj   +1 more source

Lymphocyte Induced Macrophage Cytotoxicity: Characterization of the Macrophage Cytotoxicity-Inducing Lymphocyte

Immunobiology, 1984
The phenotype of lymphocytes, obtained from mice immunized with allogeneic tumor cells, with the capacity to induce macrophage cytotoxicity was determined. Macrophage cytotoxicity was induced, either by incubating the macrophages with Macrophage Arming Factor (MAF) containing supernatants of cultures of sensitized lymphocytes and tumor cells (arming ...
E, Pels, R A, de Weger, W, den Otter
openaire   +2 more sources