Results 221 to 230 of about 1,422,099 (294)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Stress-Related Immunomodulation of Canine Lymphocyte Responses and Hematologic Profiles. [PDF]

Int J Mol Sci
Kulka M, Szopa IM, Mizera-Szpilka K, Klockiewicz M.   +3 more
europepmc   +1 more source

Immunological aspects of halo nevus (Sutton's Nevus). [PDF]

Front Immunol
Hlača N, Vičić M, Prpić-Massari L.
europepmc   +1 more source

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Science, 2020
Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes to target cells through perforin ...
Zhiwei Zhou, Huabin He, Yupeng Wang
exaly   +2 more sources

Cytotoxic Lymphocytes

2016
J. Lieberman
openaire   +2 more sources

Genotoxic and cytotoxic effects of polyethylene microplastics on human peripheral blood lymphocytes.

Chemosphere, 2021
Currently, we need emerging initial data regarding how plastic exposures affect cellular and molecular components and how such interactions will be crucial for human health.
Hayal Cobanoglu, M. Belivermiş, Ercan Sıkdokur, Ö. Kılıç, A. Çayır   +4 more
semanticscholar   +1 more source

Cytotoxic T Lymphocytes

2011
F. Jack, Bukowski, I. Kurane, '. C. Lai, Michael Bray, Barry, Falgout, A. Francis, Ennis   +8 more
semanticscholar   +3 more sources

Lymphocyte-Mediated Cytotoxicity

Annual Review of Immunology, 2002
Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that ...
John H, Russell, Timothy J, Ley
openaire   +2 more sources

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

Journal of Cellular Physiology, 2018
CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with ...
Bagher Farhood, M. Najafi, K. Mortezaee
semanticscholar   +1 more source

Cytotoxic lymphocyte‐mediated immunotherapy

Australian and New Zealand Journal of Medicine, 1995
Abstract:Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft rejection, antitumour responses, immuno regulation and some autoimmune diseases. The central importance of these cells in each of these immune responses and the therapeutic potential they offer, when effectively targeted, has justified continued interest ...
M J, Smyth, M H, Kershaw
openaire   +2 more sources