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Killing mechanisms of cytotoxic lymphocytes
Current Opinion in Hematology, 1997Killer lymphocytes are primary immune effectors of virus, certain bacteria, and tumor immunity and play a role in autoimmunity and transplant rejection. This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory, perforin/granzyme-based pathway or the nonsecretory ...
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International Archives of Allergy and Immunology, 1971
P. Perlmann, H. Perlmann
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P. Perlmann, H. Perlmann
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CD4 cytotoxic T lymphocyte differentiation
Biochimie, 1988In vitro allostimulated CD4+ human lymphocytes were cloned by micromanipulation and expanded for a short time in IL-2 conditioned medium. In the present study we observed that proliferative noncytotoxic cloned cells were able to acquire the specific cytolytic activity under some modification of the cloned cells restimulation cycle. We demonstrated that
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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Nature, 1998S. Schoenberger +4 more
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Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma
Nature, 2023, , Nora C Toussaint
exaly
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Science, 1998G. Ogg +14 more
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