Results 21 to 30 of about 1,422,099 (294)

Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine

Сибирский онкологический журнал, 2023
Purpose of the study: development of in vitro laboratory models to evaluate quality parameters and specific efficacy of dendritic cell vaccine (DCV).Material and Methods.
T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva   +8 more
doaj   +1 more source

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance None of the single-cell RNA sequencing (scRNA-seq) studies published so far convincingly identified human γδ T lymphocytes despite their anticancer functions.
Gabriele Pizzolato, H. Kaminski, M. Tosolini, D. Franchini, F. Pont, Frédéric Martins, Carine Valle, Delphine Labourdette, Sarah Cadot, A. Quillet-Mary, M. Poupot, C. Laurent, L. Ysebaert, S. Meraviglia, F. Dieli, P. Merville, P. Milpied, J. Déchanet-Merville, J. Fournié   +18 more
semanticscholar   +1 more source

Lead acetate toxicity on human lymphocytes at non-cytotoxic concentrations detected in human blood

Main Group Metal Chemistry, 2017
Lead (Pb) is one of the most important heavy metals that possess many applications in different kinds of industrial procedures and consumer products. The adverse effects of Pb on different parts of the immune system have been reported in various studies.
Zarei Mohammad Hadi, Pourahmad Jalal, Aghvami Marjan, Soodi Maliheh, Nassireslami Ehsan   +4 more
doaj   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Nature Communications, 2021
Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation.
B. Weigelin, A. D. den Boer, E. Wagena, K. Broen, H. Dolstra, Rob J. de Boer, C. Figdor, J. Textor, P. Friedl   +8 more
semanticscholar   +1 more source

Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations

Haematologica, 2013
Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies.
Maciej Machaczka, Monika Klimkowska, Samuel C.C. Chiang, Marie Meeths, Martha-Lena Müller, Britt Gustafsson, Jan-Inge Henter, Yenan T. Bryceson   +7 more
doaj   +1 more source

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

PLoS Pathogens, 2020
Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan, Shuang Li, Jan Meeldijk, Bernadet Blijenberg, Astrid Hendriks, Karlijn J W M van Boxtel, Sara P H van den Berg, Ian J Groves, Martin Potts, Adriana Svrlanska, Thomas Stamminger, Mark R Wills, Niels Bovenschen   +12 more
doaj   +1 more source

Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Frontiers in Immunology, 2017
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular infections as well as physiological stress. Cytotoxic lymphocytes combat intracellular infections.
Jakob Theorell, Indre Bileviciute-Ljungar, Indre Bileviciute-Ljungar, Bianca Tesi, Bianca Tesi, Heinrich Schlums, Mette Sophie Johnsgaard, Babak Asadi-Azarbaijani, Babak Asadi-Azarbaijani, Elin Bolle Strand, Elin Bolle Strand, Yenan T. Bryceson, Yenan T. Bryceson   +12 more
doaj   +1 more source

Cytotoxic T Lymphocytes in Rasmussen’s Encephalitis

Pediatric Neurology Briefs, 2002
The role of cytotoxic T lymphocytes and other mechanisms in the pathogenesis of Rasmussen’s encephalitis (RE) is reviewed at the University of Vienna, Austria, and the University of Bonn, Germany.
J Gordon Millichap
doaj   +1 more source

Towards Understanding the Lymph Node Response to Skin Infection with Saprophytic Staphylococcus epidermidis

Biomedicines, 2022
In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. The response of major cell subpopulations in the draining lymph nodes to skin infection with Staphylococcus epidermidis was assessed using the rat ...
Marta Cąkała-Jakimowicz, Monika Puzianowska-Kuznicka   +1 more
doaj   +1 more source